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Responsive Surfactant-Driven Morphology Transformation of Block Copolymer Microparticles.
Chemistry
January 2025
Huazhong University of Science and Technology, 1037 Luoyu Road, 430074, Wuhan, CHINA.
Block copolymer (BCP) microparticles, which exhibit rapid change of morphology and physicochemical property in response to external stimuli, represent a promising avenue for the development of programmable smart materials. Among the methods available for generating BCP microparticles with adjustable morphologies, the confined assembly of BCPs within emulsions has emerged as a particularly facile and versatile approach. This review provides a comprehensive overview of the role of responsive surfactants in modulating interfacial interactions at the oil-water interface, which facilitates controlled BCP microparticle morphology.
View Article and Find Full Text PDFSynthesis of Headful Packaging Phages Through Yeast Transformation-Associated Recombination.
Viruses
December 2024
School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China.
De novo synthesis of phage genomes enables flexible genome modification and simplification. This study explores the synthetic genome assembly of phage vB_PaeS_SCUT-S4 (S4), a 42,932 bp headful packaging phage, which encapsidates a terminally redundant, double-stranded DNA genome exceeding unit length. We demonstrate that using the yeast TAR approach, the S4 genome can be assembled and rebooted from a unit-length genome plus a minimal 60 bp terminal redundant sequence.
View Article and Find Full Text PDFGlycyrrhizinate Monoammonium Cysteine-Loaded Lipid Nanoparticles Allow for Improved Acute Liver Injury Therapy.
Pharmaceutics
January 2025
Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Acute liver injury (ALI) is a prevalent and potentially lethal condition globally, where pharmacotherapy plays a vital role. However, challenges such as rapid drug excretion and insufficient concentration at hepatic lesions often impede the treatment's effectiveness. We successfully prepared glycyrrhizinate monoammonium cysteine (GMC)-loaded lipid nanoparticles (LNPs) using high-pressure homogenization.
View Article and Find Full Text PDFScalable Manufacturing Method for Model Protein-Loaded PLGA Nanoparticles: Biocompatibility, Trafficking and Release Properties.
Pharmaceutics
January 2025
MyBiotech GmbH, Industriestraße 1B, 66802 Überherrn, Germany.
: Drug delivery systems (DDSs) offer efficient treatment solutions to challenging diseases such as central nervous system (CNS) diseases by bypassing biological barriers such as the blood-brain barrier (BBB). Among DDSs, polymeric nanoparticles (NPs), particularly poly(lactic-co-glycolic acid) (PLGA) NPs, hold an outstanding position due to their biocompatible and biodegradable qualities. Despite their potential, the translation of PLGA NPs from laboratory-scale production to clinical applications remains a significant challenge.
View Article and Find Full Text PDFAnalysis on Salinity Tolerance of Lettuce Cultivars Under Saline Irrigation and Application of Organic Acids.
Plants (Basel)
January 2025
Department of Agrarian and Exact, Universidade Estadual da Paraíba, Catolé do Rocha 58884-000, PB, Brazil.
Freshwater depletion becomes a significant challenge as the population grows and food demand rises. We evaluated the responses of lettuce cultivars () under saline stress in photosynthetic responses, production, and ion homeostasis. We used a randomized block design in a 3 × 5 factorial scheme with five replications-the first factor: three cultivars of curly lettuce: SVR 2005, Simpson, and Grand Rapids.
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