AI Article Synopsis
- DNA transposons show potential for genome engineering, insertional mutagenesis, and gene therapy, with the recent clinical trials proving their efficacy.
- The article emphasizes the importance of patent information and proposes a strategy for developing transposon tools similar to strategies used in other tech fields.
- It presents a patent landscape, highlights top inventors and applicants, and discusses challenges in tracking relevant literature and patents, focusing on a promising transposon system and its impact on technological progress.
Article Abstract
DNA transposons are considered to be good candidates for developing tools for genome engineering, insertional mutagenesis and gene delivery for therapeutic purposes, as illustrated by the recent first clinical trial of a transposon. In this article we set out to highlight the interest of patent information, and to develop a strategy for the technological development of transposon tools, similar to what has been done in many other fields. We propose a patent landscape for transposon tools, including the changes in international patent applications, and review the leading inventors and applicants. We also provide an overview of the potential patent portfolio for the prokaryotic and eukaryotic transposons that are exploited by spin-off companies. Finally, we discuss the difficulties involved in tracing relevant state-of-the-art of articles and patent documents, based on the example of one of the most promising transposon systems, including all the impacts on the technological development of transposon tools.
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| http://dx.doi.org/10.1007/s10709-009-9426-3 | DOI Listing |
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