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Prophylaxis of HBV reinfection and disease in liver transplanted patients: 2024 update on the role of HBIG and cost-effectiveness evaluation.
Minerva Gastroenterol (Torino)
January 2025
Gastroenterology Department of Emergency and Organ Transplantation, University Hospital Policlinico di Bari, Bari, Italy.
Hepatitis B virus (HBV) infection is a major global health concern, with liver transplantation (LT) serving as a critical treatment for end-stage liver disease caused by HBV. However, the risk of HBV reinfection after LT remains significant, necessitating effective prophylaxis. Today, the combination of hepatitis B immune globulin (HBIG) and high-barrier nucleos(t)ide analogues (NUCs) is the standard of care for preventing HBV recurrence post-LT but concerns about the cost of HBIG and access to high-barrier NUCs have led to a reduction in the use, dose, and duration of HBIG in recent years.
View Article and Find Full Text PDFRandomized controlled trials of digital health interventions for rheumatic disease management: a systematic review.
Bull World Health Organ
February 2025
Department of Rheumatology and Immunology, Singapore General Hospital, Singapore.
Objective: To evaluate the adoption, effectiveness and cost-effectiveness of digital health interventions for rheumatic disease management.
Methods: Between 25 May 2024 and 2 June 2024, we systematically searched PubMed®, Scopus, ClinicalTrials.gov, the Global Observatory for eHealth and the World Bank Open Knowledge Repository for randomized controlled trials (RCTs) evaluating digital health interventions for rheumatic disease management.
Microbiome and Colorectal Cancer in Humans: A Review of Recent Studies.
J Anus Rectum Colon
January 2025
Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan.
The tumor microenvironment has recently been well-studied in various gastrointestinal cancers, including colorectal cancer (CRC). The gut microbiota, a collection of microorganisms in the human gastrointestinal tract, is one of the microenvironments associated with colon carcinogenesis. It has been challenging to elucidate the mechanisms by which gut microbiota contributes to carcinogenesis and cancer progression due to complex interactions with the host, including its metabolites and immune and inflammatory responses.
View Article and Find Full Text PDFRetraction: Advancing Perioperative Neurocognitive Health: A Critical Review of Predictive Tools, Diagnostic Methods, and Interventional Strategies.
Cureus
January 2025
Internal Medicine, Faisalabad Medical University, Faisalabad, PAK.
[This retracts the article DOI: 10.7759/cureus.59436.
View Article and Find Full Text PDFTherapeutic strategies targeting CD47-SIRPα signaling pathway in gastrointestinal cancers treatment.
J Pharm Anal
January 2025
School of Life Sciences, Chongqing University, Chongqing, 401331, China.
Gastrointestinal (GI) cancers are prevalent globally, with leading incidence and mortality rates among malignant tumors. Despite notable advancements in surgical resection, radiotherapy, and chemotherapy, the overall survival rates remain low. Hence, it is imperative to explore alternative approaches that enhance patient outcomes.
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