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Pharmacogenomics of taxane/platinum therapy in ovarian cancer. | LitMetric

Pharmacogenomics of taxane/platinum therapy in ovarian cancer.

Int J Gynecol Cancer

Génome Québec and Montreal Heart Institute Pharmacogenomics Centre, 5000 rue Bélanger, Montreal, Quebec, Canada.

Published: December 2009

AI Article Synopsis

Article Abstract

Objectives: Taxane (paclitaxel or docetaxel) and platinum (cisplatin or carboplatin) chemotherapy is commonly used in the treatment of ovarian cancer. Despite an initial high response to therapy, the 5-year survival rate remains low. The identification of pharmacogenomic markers to identify patients unlikely to respond or at risk for severe toxicity will assist in the goal of individualizing ovarian cancer treatment.

Materials And Methods: Most studies have assessed single nucleotide polymorphisms from genes involved in the pharmacokinetics and pharmacodynamics of the drugs.

Results: Unfortunately, most markers identified have not been replicated in subsequent studies.

Conclusions: Other mechanisms of variability, including epigenetic control of gene expression and copy number variation, may play important roles. In addition, nongenetic influences such as concurrent medications, and physiological and environmental factors could also affect individual responses to taxane and platinum therapy.

Download full-text PDF

Source
http://dx.doi.org/10.1111/IGC.0b013e3181c10513DOI Listing

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