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Acta Radiol
March 2025
Department of Laboratory Medicine, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, Jiangsu, PR China.
BackgroundBreast cancer is a prevalent cancer affecting women globally, with incidence rates rising rapidly.PurposeTo examine the diffusion tensor imaging (DTI) data of patients with breast cancer before and after chemotherapy through tract-based spatial statistical analysis (TBSS).Material and MethodsCognitive and neuropsychological tests and whole-brain DTI were administered to patients with breast cancer who did not receive postoperative chemotherapy (C-) or received postoperative chemotherapy (C+) and healthy controls (HCs).
View Article and Find Full Text PDFJ Am Geriatr Soc
March 2025
College of Nursing, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Background: Surgical resection is the primary treatment modality for colorectal cancer. Prehabilitation is about enhancing the patient's physiological capacity preoperatively to reduce the risk of treatment-related complications. Clear definitions of the modality, content, and duration of prehabilitation, including its components such as nutrition, exercise, and psychological support, are lacking.
View Article and Find Full Text PDFMinim Invasive Ther Allied Technol
March 2025
Department of Gastrointestinal Surgery/Breast Surgery, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
Background: The optimal reconstruction route after esophagectomy remains controversial. The retrosternal route has the advantage of a lower risk of fatal complications. However, the blind maneuver to create a retrosternal route may cause bleeding and pleural injury.
View Article and Find Full Text PDFJ Appl Clin Med Phys
March 2025
Department of Comprehensive Radiation Oncology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Purpose: This study aims to quantify and compare the dosimetric effects of varying thicknesses of StrataXRT, a silicone-based gel, and other topical agents on the skin surface during volumetric modulated arc therapy (VMAT) for breast cancer.
Methods: A VMAT plan was created for breast cancer treatment using a female RANDO phantom with a prescription dose of 50 Gy in 25 fractions. The planning target volume (PTV) encompassed the left breast and the regional lymph nodes.
Chem Biol Drug Des
March 2025
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mersin University, Mersin, Türkiye.
This study presents the design, synthesis, and biological evaluation of a series of novel pyrrole-tethered bisbenzoxazole (PTB) derivatives as potential apoptosis-inducing agents targeting the MCF-7 human breast cancer cell line. The anticancer activity of these compounds was evaluated in vitro using the MTT assay, with tamoxifen serving as the reference therapeutic agent. Compounds B8, B14, and B18 demonstrated remarkable cytotoxicity against MCF-7 cells, exhibiting approximately 8-fold lower IC values compared to tamoxifen, while showing minimal effects on healthy fibroblasts.
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