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http://dx.doi.org/10.3324/haematol.2009.018663 | DOI Listing |
Biogerontology
March 2025
Department of Biotechnology, Faculty of Science and Technology (FOST), University of Central Punjab (UCP), 1- Khayaban-E-Jinnah Road, Johar Town Lahore, Pakistan.
Aging is a principal driver of cardiomyopathy, characterized by mitochondrial dysfunction, oxidative stress, and progressive telomere shortening in cardiomyocytes. These pathological changes impair cellular bioenergetics and regenerative capacity, accelerating cardiac deterioration. However, targeted interventions to mitigate these effects remain limited.
View Article and Find Full Text PDFClin Exp Med
March 2025
Hangzhou Normal University School of Nursing, Hangzhou, China.
The intensifying global phenomenon of an aging population has spurred a heightened emphasis on studies on aging and disorders associated with aging. Cellular senescence and aging are known to be caused by telomere shortening. Telomere length (TL) has emerged as a biomarker under intense scrutiny, and its widespread use in investigations of diseases tied to advancing age.
View Article and Find Full Text PDFBiol Proced Online
February 2025
Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Background: Hepatocellular carcinoma (HCC) is a prevalent malignancy worldwide, characterized by its high malignancy and poor prognosis. Telomeres, crucial components of eukaryotic chromosomes, have been increasingly recognized for their involvement in tumorigenesis, development, and impact on the prognosis of cancer patients. However, the precise role of telomere-associated genes in HCC remains incompletely elucidated.
View Article and Find Full Text PDFInt J Mol Sci
February 2025
State Key Laboratory of Molecular Neuroscience, Institute for Advanced Study, Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China.
G-quadruplexes (G4s) are unique nucleic acid structures composed of guanine-rich (G-rich) sequences that can form diverse topologies based on the arrangement of their four strands. G4s have attracted attention for their potential roles in various biological processes and human diseases. In this review, we focus on the G4 structures formed by human telomeric sequences, (GGGTTA), and the hexanucleotide repeat expansion, (GGGGCC), in the first intron region of the chromosome 9 open reading frame 72 () gene, highlighting their structural diversity and biological significance.
View Article and Find Full Text PDFBiomolecules
February 2025
Dipartimento di Chimica, Università di Pavia, V.le Taramelli 10, 27100 Pavia, Italy.
Within the framework of rational drug design, this study introduces a novel approach to enhance the specificity of small molecules in targeting cancer cells. This approach starts from the use of dyads merging into a single entity, a naphthalene diimide (NDI) and core-extended NDI (ceNDI), both known as G-quadruplex (G4) ligands and fluorescent probes. The strategy aims to leverage the unique diagnostic strengths of the ceNDI moiety featuring red emission by improving its binding affinity and target selectivity through inclusion in dyads built with different linkers.
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