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Enantioselective total synthesis of (-)-(S)-stepholidine. | LitMetric

Enantioselective total synthesis of (-)-(S)-stepholidine.

J Org Chem

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Published: December 2009

Enantioselective total synthesis of (-)-(S)-stepholidine, a drug candidate for the treatment of schizophrenia and/or drug abuse, is described. Asymmetric transfer hydrogenation of imines with use of Noyori's catalyst was used as the key step and (-)-(S)-stepholidine was synthesized in 6 steps, with 42% overall yield and >99% ee.

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Source
http://dx.doi.org/10.1021/jo9020826DOI Listing

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