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Infants' Social Evaluation of Helpers and Hinderers: A Large-Scale, Multi-Lab, Coordinated Replication Study.
Dev Sci
January 2025
Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada.
Evaluating whether someone's behavior is praiseworthy or blameworthy is a fundamental human trait. A seminal study by Hamlin and colleagues in 2007 suggested that the ability to form social evaluations based on third-party interactions emerges within the first year of life: infants preferred a character who helped, over hindered, another who tried but failed to climb a hill. This sparked a new line of inquiry into the origins of social evaluations; however, replication attempts have yielded mixed results.
View Article and Find Full Text PDFHousing and Husbandry Factors Affecting Zebrafish () Novel Tank Test Responses: A Global Multi-Laboratory Study.
Res Sq
October 2024
Surrey Sleep Research Centre, Department of Clinical and Experimental Medicine, School of Biosciences, University of Surrey, Guildford, Surrey, GU2 7XH, UK.
The reproducibility crisis in bioscience, characterized by inconsistent study results, impedes our understanding of biological processes and global collaborative studies offer a unique solution. This study is the first global collaboration using the zebrafish () novel tank test, a behavioral assay for anxiety-like responses. We analyzed data from 20 laboratories worldwide, focusing on housing conditions and experimental setups.
View Article and Find Full Text PDFFrom early on, infants show a preference for infant-directed speech (IDS) over adult-directed speech (ADS), and exposure to IDS has been correlated with language outcome measures such as vocabulary. The present multi-laboratory study explores this issue by investigating whether there is a link between early preference for IDS and later vocabulary size. Infants' preference for IDS was tested as part of the ManyBabies 1 project, and follow-up CDI data were collected from a subsample of this dataset at 18 and 24 months.
View Article and Find Full Text PDFA rigorous multi-laboratory study of known PDAC biomarkers identifies increased sensitivity and specificity over CA19-9 alone.
Cancer Lett
November 2024
University of Pittsburgh Medical Center, 200 Lothrop St., Pittsburgh, PA, 15213-2582, USA. Electronic address:
A blood test that enables surveillance for early-stage pancreatic ductal adenocarcinoma (PDAC) is an urgent need. Independent laboratories have reported PDAC biomarkers that could improve biomarker performance over CA19-9 alone, but the performance of the previously reported biomarkers in combination is not known. Therefore, we conducted a coordinated case/control study across multiple laboratories using common sets of blinded training and validation samples (132 and 295 plasma samples, respectively) from PDAC patients and non-PDAC control subjects representing conditions under which surveillance occurs.
View Article and Find Full Text PDFDetermination of Aloin A, Aloin B, and Aloe-Emodin in Raw Materials and Finished Products Using HPLC Multi-Laboratory Validation Study, AOAC 2016.09, Final Action Status.
J AOAC Int
September 2024
Herbalife Nutrition, 990 West 190th Street, Torrance, CA, 90502.
Article Synopsis
- A multi-laboratory validation study was conducted to assess the AOAC OMA 2016.09 method, involving eight labs worldwide that tested six different raw materials and formulated products, all meeting acceptance criteria.
- The study focused on evaluating specificity, precision, linearity/range, system suitability, limit of detection (LOD), and limit of quantitation (LOQ), as accuracy and ruggedness had already been validated previously.
- Results indicated no major interferences in chromatograms for aloin A, aloin B, and aloe-emodin, with high precision (≤ 0.05 ppm differences) and strong linearity (R ≥ 0.999 across standards), confirming the method's reliability.
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