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Attempts to Create Transgenic Mice Carrying the Q3924E Mutation in RyR2 Ca Binding Site.
Cells
December 2024
Cardiac Signaling Center, University of South Carolina, Medical University of South Carolina and Clemson University, Charleston, SC 29425, USA.
Over 200 point mutations in the ryanodine receptor (RyR2) of the cardiac sarcoplasmic reticulum (SR) are known to be associated with cardiac arrhythmia. We have already reported on the calcium signaling phenotype of a point mutation in RyR2 Ca binding site Q3925E expressed in human stem-cell-derived cardiomyocytes (hiPSC-CMs) that was found to be lethal in a 9-year-old girl. CRISPR/Cas9-gene-edited mutant cardiomyocytes carrying the RyR2-Q3925E mutation exhibited a loss of calcium-induced calcium release (CICR) and caffeine-triggered calcium release but continued to beat arrhythmically without generating significant SR Ca release, consistent with a remodeling of the calcium signaling pathway.
View Article and Find Full Text PDFHSF-IBI: A Universal Framework for Extracting Inter-Beat Interval from Heterogeneous Unobtrusive Sensors.
Bioengineering (Basel)
December 2024
Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing 100190, China.
Heartbeat inter-beat interval (IBI) extraction is a crucial technology for unobtrusive vital sign monitoring, yet its precision and robustness remain challenging. A promising approach is fusing heartbeat signals from different types of unobtrusive sensors. This paper introduces HSF-IBI, a novel and universal framework for unobtrusive IBI extraction using heterogeneous sensor fusion.
View Article and Find Full Text PDFPrevalence of meconium-stained amniotic fluid and factors associated with emergency cesarean section: multicenter cross-sectional study in south central Ethiopia.
Front Glob Womens Health
December 2024
College of Medicine and Health Sciences, Bahirdar University, Bahirdar, Ethiopia.
Background: Meconium is thick black-green fetal intestinal content starting from the early first trimester of gestation. Unfortunately, if it is released into the amniotic cavity due to any cause, it can be associated with neonatal mortality and morbidity.
Objective: To identify the factors associated with meconium-stained amniotic fluid among mothers undergoing emergency cesarean section in specialized hospitals cross-sectional study in south central Ethiopia from August 1, 2022, to 30, October 2022.
Prediction of ECG signals from ballistocardiography using deep learning for the unconstrained measurement of heartbeat intervals.
Sci Rep
January 2025
Department of Biosystems Engineering, Graduate School of Science and Engineering, Yamagata University (emeritus), Yonezawa, Japan.
We developed a deep learning-based extraction of electrocardiographic (ECG) waves from ballistocardiographic (BCG) signals and explored their use in R-R interval (RRI) estimation. Preprocessed BCG and reference ECG signals were inputted into the bidirectional long short-term memory network to train the model to minimize the loss function of the mean squared error between the predicted ECG (pECG) and genuine ECG signals. Using a dataset acquired with polyvinylidene fluoride and ECG sensors in different recumbent positions from 18 participants, we generated pECG signals from preprocessed BCG signals using the learned model and evaluated the RRI estimation performance by comparing the predicted RRI with the reference RRI obtained from the ECG signal using a leave-one-subject-out cross-validation scheme.
View Article and Find Full Text PDF[Cardiotoxicity risk assessment of anticancer drugs by focusing on mitochondrial quality of human iPS cell-derived cardiomyocytes].
Nihon Yakurigaku Zasshi
January 2025
Graduate School of Pharmaceutical Science, Kyushu University.
Currently, a variety of anticancer agents are used in the treatment of cancer. Since anticancer agents are used continuously over a long time, they carry the risk of side effects. One of the major side effects is cardiac dysfunction.
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