AI Article Synopsis
- The study aimed to explore how Pueraria can prevent age-related hearing loss (presbycusis) in older rats.
- Thirty-two Wistar rats were divided into four groups and given different dosages of Pueraria for 4 weeks, with their hearing tested through auditory brainstem response (ABR) and blood flow metrics.
- The results showed significant improvement in hearing and blood flow for rats treated with Pueraria, with 2 g/(kg x d) being the most effective dosage that provided the best results with fewer side effects.
Article Abstract
Objective: To investigate the preventive effects of Pueraria on presbycusis in rats.
Method: Thirty-two 24-26 month old Wistar rats were randomly divided into four groups, and were treated with different dosages of Pueraria (1, 2, 4, 0 g x kg(-1) x d(-1)) separately for 4 weeks. Auditory brainstem response (ABR) was used to detect the change of hearing threshold of rats. Hemorheological items of rats were checked in each group.
Result: Compared with control group, the hearing threshold and hemorheological items of rats was significantly improved after treated with Pueraria (P<0.05). In addition, 2 g/(kg x d) was found to be the best dosage of Pueraria for rats, which can achieve ideal effect with minimum side effect.
Conclusion: Pueraria could improve tiny circulation, has good preventive effect on presbycusis of rats.
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