AI Article Synopsis
- The study examined how an antileptin antibody affects puberty onset in female rats, specifically looking at the timing of vaginal opening (VO) and its relation to leptin, LH, and body weight.
- Results showed that the antileptin group experienced a delay in VO, occurring at day 34 compared to day 30 in the control group (P < .01).
- Although body weight increased in the antileptin group, there was no significant difference in serum leptin and LH levels between the two groups during VO, indicating that central leptin plays a crucial role in initiating puberty independently of body weight and serum leptin levels.
Article Abstract
The effect of intracerebroventricular (ICV) antileptin antibody on the onset of puberty in the female rat and the relationship between serum leptin, luteinizing hormone (LH), and body weight were investigated. Antileptin antibody (group A) was infused ICV from days 23-36 in prepubertal female rats whereas the control (group B) received ICV goat immunoglobulin G (IgG). In the antileptin group, mean day of vaginal opening (VO) was postponed (day 34 versus day 30, P < .01 ). Body weight trended higher after 30 days in the antileptin group but not significantly. However, there was no difference in serum leptin and LH between the two groups on the day of VO. Serum leptin was relatively constant from day 23 through day 31 and did not correlate with LH (r = 0.14, P = .10). These studies demonstrate that central leptin promotes the onset of female rat puberty as evidenced by VO. Finally, central leptin impacts female rat pubertal onset in distinction from serum leptin and body weight.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777280 | PMC |
| http://dx.doi.org/10.1155/2009/194807 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!