AI Article Synopsis
- Multiple hypotheses exist about how temporal lobe epilepsy (TLE) begins, but most focus on changes in specific brain areas and can't fully explain the condition due to its complexity.
- Extensive damage and reorganization of neurons make it difficult to pinpoint a single cause of epilepsy since different individuals may have varying underlying changes in the brain.
- The review will summarize structural changes in brain regions linked to TLE, highlight their functional importance, and discuss future research directions.
Article Abstract
While different hypotheses have been proposed to explain the mechanism of onset of temporal lobe epilepsy (TLE), most of them are based on structural, electrophysiological, cellular or molecular changes in one particular area. Extensive neuronal loss, axon reorganization, dendrite and dendritic spine growth make it impossible to apply one hypothesis to explain epileptogenesis for patients or animal models with different pathophysiological changes in the brain. It is therefore hypothesized that cyto-, axo- and dendro-architectonic changes at multiple brain regions may be involved in epileptogenesis in TLE. In the review, structural changes of the limbic system, in particular, hippocampus, entorhinal cortex, subiculum and amygdale, in the mouse pilocarpine model of TLE will be summarized. Their functional significance will be discussed. The final conclusion and future research directions will then be made.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.eplepsyres.2009.10.015 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The therapeutic profile of rolipram, PDE target and mechanism of action as a neuroprotectant following spinal cord injury.
PLoS One
March 2013
The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, United States of America.
The extent of damage following spinal cord injury (SCI) can be reduced by various neuroprotective regimens that include maintaining levels of cyclic adenosine monophosphate (cyclic AMP), via administration of the phosphodiesterase 4 (PDE4) inhibitor Rolipram. The current study sought to determine the optimal neuroprotective dose, route and therapeutic window for Rolipram following contusive SCI in rat as well as its prominent PDE target and putative mechanism of protection. Rolipram or vehicle control (10% ethanol) was given subcutaneously (s.
View Article and Find Full Text PDFCyto-, axo- and dendro-architectonic changes of neurons in the limbic system in the mouse pilocarpine model of temporal lobe epilepsy.
Epilepsy Res
March 2010
Temasek Laboratories, National University of Singapore 5A, Engineering Drive 1, Singapore 117411, Singapore.
Article Synopsis
- Multiple hypotheses exist about how temporal lobe epilepsy (TLE) begins, but most focus on changes in specific brain areas and can't fully explain the condition due to its complexity.
- Extensive damage and reorganization of neurons make it difficult to pinpoint a single cause of epilepsy since different individuals may have varying underlying changes in the brain.
- The review will summarize structural changes in brain regions linked to TLE, highlight their functional importance, and discuss future research directions.
Immunocytochemistry and calcium cytochemistry of the mammalian pineal organ: a comparison with retina and submammalian pineal organs.
Microsc Res Tech
May 1992
Neuroendocrine Section, Hungarian Academy of Sciences, Semmelweis University Medical School, Budapest.
Morphologically the mammalian pineal organ is a part of the diencephalon. It represents a neural tissue histologically ("pineal nervous tissue") and is dissimilar to endocrine glands. Submammalian pinealocytes resemble the photoreceptor cells of the retina, and some of their cytologic characteristics are preserved in the mammalian pinealocytes together with compounds demonstrable by cyto- and immunocytochemistry and participating in photochemical transduction.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!