AI Article Synopsis
- The study aimed to assess the effects of mitomycin-C (MMC) on preventing fibrosis in the external auditory canal (EAC) using a guinea pig model.
- Sixteen guinea pigs were divided into two groups; one group received MMC after an injury to the EAC, while the control group received saline.
- Results showed that the MMC-treated group experienced less fibrosis compared to the control group, indicating that MMC may help reduce EAC fibrosis following injury.
Article Abstract
Objective: The aim of this study was to investigate the preventive effect of mitomycin-C (MMC) on external auditory canal (EAC) fibrosis in an animal model.
Study Design: This is a randomized, controlled animal study.
Subjects And Methods: Sixteen guinea pigs were used for this study. After the skin of cartilaginous EAC was injured with an electrocautery, the cottonoid soaked in MMC solution with concentration of 0.4 mg/mL was topically applied for 5 minutes to the injured EAC in an MMC-treated group (n = 8). In addition, saline was applied in the control group (n = 8). At 4 weeks after injury, postsurgical changes of EAC were evaluated by histologic examination.
Results: External auditory canal fibrosis was induced by injury with electrocautery. The MMC-treated group showed less degree of fibrosis without differences in epithelialization and inflammatory cell infiltration.
Conclusion: This study suggests that MMC can be helpful in preventing EAC fibrosis after injury.
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| http://dx.doi.org/10.1016/j.amjoto.2008.08.013 | DOI Listing |
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