AI Article Synopsis
- Local injection of 5-fluorouracil (5-FU) has shown positive outcomes for patients with early gastric cancer, but this study focuses on its effects in advanced gastric cancer (AGC).
- Endoscopic injection of 5-FU was performed on three AGC patients who were not candidates for surgery or traditional chemotherapy, and the treatment proved to be well-tolerated with a significant reduction in tumor size.
- The findings suggest that endoscopic chemotherapy with 5-FU is a promising option for specific AGC patients, although more research is needed to confirm these results.
Article Abstract
Introduction: It has been reported that a local injection of 5-fluorouracil (5-FU) administered endoscopically can have a favorable result in patients with early gastric cancer.
Methods: We report the application of a local injection of 5-FU administered endoscopically in three patients with advanced gastric cancer (AGC) who refused or were not suitable for surgery or systemic chemotherapy. The benefits of locally applied endoscopic chemotherapy (EC) with 5-FU as an alternative therapy were evaluated.
Results: Good tolerance with an important reduction of the tumor size and no adverse reactions was observed in all three patients.
Conclusion: EC with 5-FU is a feasible technique that can be applied in a certain group of patients with AGC. Further studies will be required to corroborate these results.
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| http://dx.doi.org/10.1007/s12029-009-9112-9 | DOI Listing |
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