Objective: The management of neurovascular disease requires precise information on the cerebral vascular anatomy. Digital subtraction angiography (DSA) is the gold standard against which other imaging modalities have to be measured. To improve the quality of three-dimensional (3D) magnetic resonance angiography (MRA) images, we present a novel concept in 3D image analysis.
Methods: Five patients, harboring cerebral aneurysm, underwent DSA, computed tomography angiography (CTA) and MRA. MRA data were processed using a novel anisotropic curvature motion model. Three-dimensional reconstructions of CTA and MRA datasets were used for comparison.
Results: The 3D-reconstructed images accurately displayed all aneurysms. The anatomy of the anterior part of the circle of Willis was visualized reliably. The smoothened vessel surfaces enhanced the readability of the images. Regarding visual representation of the posterior part of the circle of Willis, the post-processed MRA showed the arterial segments less accurate than the standard modalities.
Conclusions: This new approach is a promising tool for planning of neurovascular interventions and preoperative evaluation.
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http://dx.doi.org/10.1179/016164110X12556180206077 | DOI Listing |
SLAS Discov
January 2025
Bonds Biosystems, 27 Strathmore Rd, Natick, MA, USA. Electronic address:
Obesity and type 2 diabetes (T2D) are strongly linked to abnormal adipocyte metabolism and adipose tissue (AT) dysfunction. However, existing adipose tissue models have limitations, particularly in the stable culture of fat cells that maintain physiologically relevant phenotypes, hindering a deeper understanding of adipocyte biology and the molecular mechanisms behind differentiation. Current model systems fail to fully replicate in vivo metabolism, posing challenges in adipose research.
View Article and Find Full Text PDFMagn Reson Med
January 2025
Department 8.1 - Biomedical Magnetic Resonance, Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany.
Purpose: To develop a low-cost, high-performance, versatile, open-source console for low-field MRI applications that can integrate a multitude of different auxiliary sensors.
Methods: A new MR console was realized with four transmission and eight reception channels. The interface cards for signal transmission and reception are installed in PCI Express slots, allowing console integration in a commercial PC rack.
Dalton Trans
January 2025
School of Materials Science and Engineering, Jiangsu University of Science and Technology, Zhenjiang 212100, Jiangsu, China.
Five alkali metal manganese(III) fluorophosphates, KMn(POF)F (I), RbMn(POF)F (II), RbMn(POF)(PO)F (III), RbMn(POF)(PO)F (IV), and CsMn(POF)F (V), were successfully synthesized using a hydrothermal method. The monofluorophosphate anion (POF) groups work as "chemical scissors" to promote low-dimensional spin structures with the aid of alkali metal cations. I and II had an = 2 uniform chain structure formed by corner-sharing -MnOF octahedra.
View Article and Find Full Text PDFCureus
December 2024
Department of Neurosurgery, Fukuoka University, Fukuoka, JPN.
Osteoporotic vertebral fractures (OVF) commonly occur at the thoracolumbar junction, and delayed neurological deficits are rare. Here, a 76-year-old female presented with low back pain and the late onset of symptoms characterized by lumbar radiculopathy. She had been suffering from lower back pain for four weeks and developed lumbar radiculopathy in the left L3 area.
View Article and Find Full Text PDFACS Omega
January 2025
Science Division, New York University Abu Dhabi, P.O. Box 129188, Abu Dhabi, United Arab Emirates.
Determining the structure of sitagliptin is crucial for ensuring its effectiveness and safety as a DPP-4 inhibitor used to treat type 2 diabetes. Accurate structure determination is vital for both drug development and maintaining quality control in manufacturing. This study integrates the advanced techniques of solid-state nuclear magnetic resonance (NMR) spectroscopy, three-dimensional (3D) electron diffraction, and density functional theory (DFT) calculations to investigate the structural intricacies of sitagliptin.
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