AI Article Synopsis
- Telomeres play a role in cellular aging and are shorter in individuals with heart failure, but their significance for prognosis had not been previously established.
- A study of 890 heart failure patients revealed that those with shorter telomeres had a higher risk of death or hospitalization over 18 months.
- The findings indicate that shorter telomere length is a predictor of poorer outcomes in chronic heart failure patients, even when accounting for other health factors.
Article Abstract
Background: Telomeres are causally involved in senescence. Senescence is a potential factor in the pathogenesis and progression of heart failure. In heart failure telomeres are shorter, but the prognostic value associated with telomere length has not been defined.
Methods: Telomere length was prospectively determined by quantitative polymerase chain reaction in 890 patients with New York Heart Association (NYHA) functional class II to IV heart failure. After 18 months, we examined the association between telomere length and the predefined primary end-point: time to death or hospitalization for heart failure.
Results: Mean age of the patients was 71 years, 39% were women, 51% were in NYHA class II, and 49% were in class III/IV. A total of 344 patients reached the primary end-point (130 deaths and 214 hospitalizations). Patients with shorter telomeres were at an increased risk of reaching the primary end-point (hazard ratio 1.79; 95% confidence interval (CI) 1.21-2.63). In multivariate analysis shorter telomere length remained associated with a higher risk for death or hospitalization (hazard ratio, 1.74; 95% CI 1.07-2.95) after adjustment for age of heart failure onset, gender, hemoglobin, renal function, and N-terminal pro-B-type natriuretic peptide level, a history of stroke, atrial fibrillation, and diabetes.
Conclusions: Shorter length of telomeres predicts the occurrence of death or hospitalization in patients with chronic heart failure.
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| http://dx.doi.org/10.3109/07853890903321567 | DOI Listing |
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