We report a case of a 55-year-old female presenting with headache. Neuroradiological investigations revealed a fusiform aneurysm at the M3 part of the right middle cerebral artery. The aneurysm rapidly developed in the course of one year. She underwent a craniotomy for superficial temporal artery middle cerebral artery bypass (STA-MCA bypass) and resection of the aneurysm. Pathological examination suggested that atherosclerosis was a predisposing factor for aneurysm formation. Although she had developed transient dysarthria and left-hand clumsiness after the operation, she was able to be discharged after 26 days with no neurological deficits. On reviewing the literature, fusiform aneurysms seem to be an important cause of subarachnoid hemorrhage and cerebral infarction of unverified origin. Etiology and treatment of spontaneous fusiform aneurysms in a branch of the middle cerebral artery are also discussed.
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Alzheimers Dement
January 2025
Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
Introduction: Plasma phosphorylated tau (p-tau) biomarkers have improved Alzheimer's disease (AD) diagnosis, but data from diverse Asian populations are limited. This study evaluated plasma p-tau217 and p-tau181 levels in Korean and Taiwanese populations.
Methods: All participants (n = 270) underwent amyloid positron emission tomography (PET) and blood tests.
Clin Appl Thromb Hemost
January 2025
Department of Pharmacy Practice, Loma Linda University School of Pharmacy, Loma Linda, CA, USA.
Limited available evidence comparing DOACs with warfarin suggests efficacy and safety of DOACs for CVT. We aimed to evaluate whether a specific DOAC is preferred for the treatment of CVT. This retrospective cohort study included adult patients with CVTs between September 2018 and September 2022 treated with a DOAC.
View Article and Find Full Text PDFWorld J Gastroenterol
January 2025
Department of Radiology, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou Medical Center, Changzhou 213000, Jiangsu Province, China.
Background: Anxiety is a common comorbidity in patients with Crohn's disease (CD). Data on the imaging characteristics of brain microstructure and cerebral perfusion in CD with anxiety are limited.
Aim: To compare the imaging characteristics of brain microstructure and cerebral perfusion among CD patients with or without anxiety and healthy individuals.
Iran J Basic Med Sci
January 2025
Department of Basic Medicine, Chongqing Three Gorges Medical College, Chongqing 404100, China.
Objectives: Anemoside B4 (AB4) is a multifunctional compound with anti-inflammatory, anti-apoptotic, antioxidant, antiviral, and autophagy-enhancing effects. However, the role of AB4 in cerebral ischemia/reperfusion injury (CIRI) remains obscure. This experiment aims to investigate the pharmacological effects of AB4 in CIRI.
View Article and Find Full Text PDFFront Immunol
January 2025
Neuroimmunology Research Group, Netherlands Institute for Neuroscience, Amsterdam, Netherlands.
Introduction: Remyelination of demyelinated axons can occur as an endogenous repair mechanism in multiple sclerosis (MS), but its efficacy varies between both MS individuals and lesions. The molecular and cellular mechanisms that drive remyelination remain poorly understood. Here, we studied the relation between microglia activation and remyelination activity in MS.
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