AI Article Synopsis
- Genome sequences of modern human rhinoviruses (HRVs) have not been well-defined, mainly relying on data from the 1960s.
- Researchers sequenced two isolates, hrv-A101 and hrv-A101-v1, collected about eight years apart, revealing them as a unique strain within HRV-A.
- The study suggests that these strains resulted from genetic recombination of existing HRV lineages (hrv-65 and hrv-78) and indicates the presence of previously unrecognized HRV-A strains in circulation.
Article Abstract
Genome sequences of human rhinoviruses (HRV) have primarily been from stocks collected in the 1960s, with genomes and phylogeny of modern HRVs remaining undefined. Here, two modern isolates (hrv-A101 and hrv-A101-v1) collected approximately 8 years apart were sequenced in their entirety. Incorporation into our full-genome HRV alignment with subsequent phylogenetic network inference indicated that these represent a unique HRV-A, localized within a distinct divergent clade. They appear to have resulted from recombination of the hrv-65 and hrv-78 lineages. These results support our contention that there are unrecognized distinct HRV-A strains, and that recombination is evident in currently circulating strains.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910715 | PMC |
| http://dx.doi.org/10.1007/s00705-009-0549-8 | DOI Listing |
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