Glucose homeostasis and weight loss in morbidly obese patients undergoing banded sleeve gastrectomy: a prospective clinical study.

Objective: To assess glucose homeostasis and weight loss in morbidly obese patients undergoing Silastic(R) ring sleeve gas-trectomy.

Methods: This was a prospective clinical study. Thirty-three female patients with a mean body mass index (BMI) of 42.33 +/- 1.50 kg/m(2) (range: 40-45 kg/m(2)), a mean age of 36.7 +/- 9.4 years and a mean waist circumference of 118.7 +/- 5.98 cm were included in this study. Type 2 diabetes mellitus was observed in 11 patients (33.3%), and glucose intolerance was observed in 4 patients (12.1%). Mean plasma fasting glucose levels were 109.77 +/- 44.19 mg/dl (75-320) in the preoperative period. All Silastic(R) ring sleeve gastrectomy procedures were performed by the same surgical team using the same anesthetic technique. The patients were monitored for at least 12 months after surgery.

Results: The mean weight of the patients decreased from 107.69 +/- 6.57 kg to 70.52 +/- 9.36 kg (p < 0.001), the mean BMI decreased to 27.4 +/- 2.42 kg/m(2) (p < 0.001), and the mean waist circumference decreased to 89.87 cm +/- 6.66 (p < 0.001) in the postoperative period. Excess BMI loss was 86.5 +/- 14.2%. Fasting glucose levels were reduced to 80.94 +/- 6.3 mg/dl (p < 0.001). Remission of diabetes and glucose intolerance was observed in all patients.

Conclusion: Silastic(R) ring sleeve gastrectomy was effective in promoting weight loss, waist circumference reduction and control of glucose homeostasis in morbidly obese patients.