The pruning of unneeded axons and dendrites is crucial for circuitry maturation, but poorly understood on the molecular level. During metamorphosis, the transcription factor Sox14 acts as a context-dependent mediator of death, axonal or dendritic pruning. Its transcriptional target Mical acts specifically in dendrite pruning.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193127 | PMC |
| http://dx.doi.org/10.1038/nn1209-1479 | DOI Listing |
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