AI Article Synopsis
- The scientific community is studying the new pandemic H1N1 strain to understand its ancestry and enhanced virulence in humans.
- Researchers have identified a specific genetic mutation (S12Stop) in the PB1-F2 protein, which is linked to the virus's ability to cause disease.
- This discovery could help explain why the H1N1 strain is rarely found in pig populations and improve our understanding of its transmission and effects during the 2009 pandemic.
Article Abstract
As the scientific community scrambles to define the ancestry and lineages of the eight segments of new pandemic H1N1 strain, we looked for unique genetic events in this virus's genome to explain the newly found enhanced virulence and transmissibility among humans. Genome annotations of this virus identified a stop mutation replacing serine at codon 12 (S12Stop) of the PB1-F2 protein, a virulence factor in influenza A viruses. Here, we discuss the significance of this finding and how it may contribute to host specialization, explaining the virtual absence of the H1N1 influenza A virus strain in pig populations. This finding is expected to lead to a better understanding of the transmission and pathogenesis of the 2009 pandemic strain.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807273 | PMC |
| http://dx.doi.org/10.4142/jvs.2009.10.4.349 | DOI Listing |
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