Highly selective and potent mu opioid ligands by unexpected substituent on morphine skeleton.

Bioorg Med Chem Lett

Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China.

Published: January 2010

Unexpected substituent on the well-known morphine skeleton is described to be account for highly selective and potent mu opioid ligands, which is strongly connected to substituted aromatic groups on this omitted 8alpha-position.

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Source
http://dx.doi.org/10.1016/j.bmcl.2009.07.119DOI Listing

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