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Solitary Fibrous Tumor of the Larynx: A Case Report and Brief Literature Review.
Ear Nose Throat J
November 2024
Department of Head and Neck Surgery, Orlando Health Cancer Institute, Orlando, FL, USA.
Solitary fibrous tumors (SFTs) are a rare type of soft tissue tumor first identified as arising from pleura and usually arising in the thoracic cavity. The incidence of SFTs arising in the head and neck region is much lower, accounting for about 7% of SFT cases. Involvement of the larynx specifically is exceedingly rare and can have inconspicuous presentations, making them challenging to diagnose.
View Article and Find Full Text PDFAfferent and Efferent Connections of the Postinspiratory Complex (PiCo) Revealed by AAV and Monosynaptic Rabies Viral Tracing.
J Comp Neurol
November 2024
Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington, USA.
The control of the respiratory rhythm and airway motor activity is essential for life. Accumulating evidence indicates that the postinspiratory complex (PiCo) is crucial for generating behaviors that occur during the postinspiratory phase, including expiratory laryngeal activity and swallowing. Located in the ventromedial medulla, PiCo is defined by neurons co-expressing two neurotransmitter markers (ChAT and Vglut2/Slc17a6).
View Article and Find Full Text PDFImmunohistochemical Evaluation of Schlafen 11 (SLFN11) Expression in Cancer in the Search of Biomarker-Informed Treatment Targets: A Study of 127 Entities Represented by 6658 Tumors.
Am J Surg Pathol
August 2024
Laboratory of Pathology, National Cancer Institute, Bethesda, MD.
Article Synopsis
- Schlafen 11 (SLFN11) is a helicase that regulates how cells respond to stress during DNA replication, and its expression can predict treatment outcomes in cancer patients receiving certain therapies.
- In a study involving 6,658 tumors, SLFN11 was found to be rare in common epithelial tumors (e.g., breast and prostate cancers) but prevalent in several more aggressive tumors and specific mesenchymal and neuroectodermal cancers.
- The absence of SLFN11 may lead to worse outcomes for patients treated with DNA-damaging drugs, suggesting the need for alternative treatments for those cancers that lack this biomarker.
Laryngeal plasmacytoma in a patient with Down's syndrome.
Autops Case Rep
August 2024
Al-Rassoul Al-Aazam Hospital, Otolaryngology-Head and Neck Surgery Department, Beirut, Lebanon.
Article Synopsis
- Extramedullary plasmacytoma is a rare tumor made up of plasma cells, usually found in soft tissues outside the bone marrow, most commonly in the head and neck region.
- A 38-year-old female with Down's syndrome experienced symptoms like hoarseness and respiratory distress, leading to the discovery of a 1x1 cm lesion in her larynx during a laryngoscopy.
- The lesion was diagnosed as a solitary extramedullary plasmacytoma, marking the first known case in a Down's syndrome patient, which highlights the need for specialized treatment and awareness of potential tumors in this demographic.
Laryngeal leiomyoma: A case report and review of literature.
World J Clin Cases
June 2024
Department of Otolaryngology, Head and Neck Surgery, The First Hospital of Jilin University, Changchun 130000, Jilin Province, China.
Article Synopsis
- Leiomyomas (LMs) are rare tumors that typically occur in smooth muscle-rich organs like the uterus and gastrointestinal tract, but a case of laryngeal leiomyoma (LLM) is discussed due to its unusual occurrence in the head and neck region.
- A 49-year-old man experienced pharyngeal discomfort and was diagnosed with LLM after surgical excision of a mass at the epiglottis, confirmed through immunohistochemical analysis.
- The study emphasizes that surgical resection is the best treatment for LLMs, highlighting the importance of early and accurate diagnosis for patient outcomes.
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