Background: Findings from various temperate regions have quite consistently shown a spring/summer peak for the occurrence of manic episodes, but inconsistencies can still be found in results from tropical regions. The present study was designed to investigate the seasonal distribution of mania and its correlations to climatic variables, in a large sample of patients visiting the emergency psychiatric room.
Methods: A hospital registry of 5172 emergency psychiatric visits for mania, 2000-2007, at a public psychiatric hospital at Belo Horizonte, Brazil (latitude 19 degrees 55' S), was analyzed. Seasonality was assessed with Cosinor Analysis. Correlations of the rate of admissions for mania to climatic variables were performed, including lagged and differenced data.
Results: A minor, but significant seasonal pattern was evidenced, with a late winter/spring peak and the nadir in February (late summer). The regression model including secular and seasonal components explained 44.4% of the variance of visits for mania. The rate of emergency visits for mania was negatively correlated to relative humidity and rainfall. Altogether, climatic variables explained 8.1% of the variance in the rate of emergency visits for mania.
Limitations: Using hospital registry data may have led to misclassification of diagnosis. The ecologic design does not account for seasonal evolution of individual cases.
Conclusion: Emergency psychiatric visits for mania were more frequent in late winter/spring, corresponding to the drier seasons of Belo Horizonte. Seasonality of mania in the tropics was corroborated by these results.
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http://dx.doi.org/10.1016/j.jad.2009.11.001 | DOI Listing |
J Affect Disord
November 2024
Brain and Mind Centre, The University of Sydney, Sydney, Australia.
Objectives: We examined associations between polygenic risk scores (PRS) for depression (PRS-MDD), psychosis (PRS-SCZ), bipolar disorders (PRS-BD) and neuroticism (PRS-NEU) and (i) help-seeking, and (ii) new onset cases of full-threshold mood or psychotic disorders in youth.
Methods: Help-seeking for mental health problems was assessed by self-report and mood and psychotic disorders were identified using the Composite International Diagnostic Interview. A principal component analysis of the four selected PRS identified two dimensions (BD-SCZ; MDD-NEU) that accounted for 69.
J Med Internet Res
October 2024
Department of Psychiatry, University of Illinois Chicago, Chicago, IL, United States.
Background: Passive sensing through smartphone keyboard data can be used to identify and monitor symptoms of mood disorders with low participant burden. Behavioral phenotyping based on mobile keystroke data can aid in clinical decision-making and provide insights into the individual symptoms of mood disorders.
Objective: This study aims to derive digital phenotypes based on smartphone keyboard backspace use among 128 community adults across 2948 observations using a Bayesian mixture model.
BMC Pregnancy Childbirth
September 2024
Department of Psychology, University of Gujrat, Gujrat, Pakistan.
The phenomenon of perinatal distress in terms of depression, anxiety, bipolar, and psychotic disorders is well-explored in the West but barely investigated in South Asia; particularly research evidence highlighting the cultural expression of couples' mental health with respect to Pakistan is rare. The purpose of this research is to focus on the exploration of psycho-socio-cultural expression of couples' perinatal distress and coping strategies used in the Pakistani context in relation to maternal and paternal mental health, with implications for the wellbeing of their unborn or born progeny. The research design focused on qualitative interpretative approaches.
View Article and Find Full Text PDFLancet Neurol
October 2024
Department of Neurology, Erasmus MC, University Medical Center, Rotterdam, Netherlands.
Background: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an autoimmune disease of the peripheral nervous system that can lead to severe disability from muscle weakness and sensory disturbances. Around a third of patients do not respond to currently available treatments, and many patients with a partial response have residual neurological impairment, highlighting the need for effective alternatives. Efgartigimod alfa, a human IgG1 antibody Fc fragment, has demonstrated efficacy and safety in patients with generalised myasthenia gravis.
View Article and Find Full Text PDFEur J Neurosci
October 2024
Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
In humans, adverse physical and/or psychological traumas in childhood may predispose to developing psychiatric disorders in adulthood, including panic disorder. To model early life adversity in mice, we subjected male and female C57BL/6 J mice to a limited bedding and nesting (LBN) protocol between postnatal days 2-9 and investigated its effect on responsiveness to panicogenic challenges in adulthood. Panic-like escape behaviour was assessed during exposure to a high concentration of CO (20%) or in the beetle mania task (BMT), used to model respiratory and non-respiratory-related types of panic respectively.
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