Aspirin (acetylsalicylic acid), the most commonly used medicinal salicylate, is an antiinflammatory, antipyretic, antirheumatic, and analgesic agent. In 2005, according to the Toxic Exposures Survey from the American Association of Poison Control Centers' National Poisoning and Exposure Database, there were more than 20,000 reported aspirin and nonaspirin salicylate exposures, 64% of which required treatment in a health care facility. Of these exposures, 50% were reported as intentional overdoses and 60 patients died.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ajem.2009.01.013 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effects of elicitors on plant host selection by adult Leptinotarsa decemlineata (Coleoptera: Chrysomelidae).
J Insect Sci
November 2024
Department of Horticulture, Oregon State University, Corvallis, OR, USA.
The Colorado Potato Beetle, Leptinotarsa decemlineata Say, is the principal defoliator of potato crops globally. It is well known for its propensity to rapidly develop resistance. Thus, new control options which are resilient to the pest's resistance capabilities are a critical need.
View Article and Find Full Text PDFSafety and efficacy of early versus delayed acetylsalicylic acid after surgery for spontaneous intracerebral haemorrhage in China (E-start): a prospective, multicentre, open-label, blinded-endpoint, randomised trial.
Lancet Neurol
December 2024
Department of Neurosurgery, Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Capital Medical University, Beijing, China.
Article Synopsis
- * A randomized trial in China involved 269 patients who were assigned to start antiplatelet therapy early (3 days post-surgery) or late (30 days post-surgery) to evaluate safety and effectiveness on major cardiovascular events.
- * The study, which involved patients mostly around 60 years old, aimed to measure occurrences of new major ischaemic events and intracranial bleeding within 90 days after surgery, and is officially registered under ClinicalTrials.gov number NCT04820972.
Investigation of the effectiveness and molecular mechanisms of thiamin priming to control early blight disease in potato.
Phytopathology
November 2024
Oregon State University, Botany and Plant Pathology, Corvallis, Oregon, United States;
Article Synopsis
- Thiamin foliar application has been shown to enhance plant immunity and effectively control some diseases, but its impact on potato diseases hasn’t been well studied.
- In this research, thiamin reduced early blight lesion sizes by about 33% when applied at 10 mM, though the protective effect was temporary and localized to the treated leaves.
- Gene expression analysis indicated that thiamin influenced the activation of numerous pathways related to plant defense and metabolism, suggesting it helps prime plant defenses by altering primary metabolism.
The Zymoseptoria tritici effector Zt-11 contributes to aggressiveness in wheat.
PLoS One
November 2024
School of Agriculture & Food Science and UCD Earth Institute, University College Dublin, Belfield, Dublin, Ireland.
Zymoseptoria tritici is an ascomycete fungus and the causal agent of Septoria tritici leaf blotch (STB) in wheat. Z. tritici secretes an array of effector proteins that are likely to facilitate host infection, colonisation and pycnidia production.
View Article and Find Full Text PDFCytomegalovirus infection of the fetal brain: intake of aspirin during pregnancy blunts neurodevelopmental pathogenesis in the offspring.
J Neuroinflammation
November 2024
Institut de Neurobiologie de la Méditerranée (INMED), Inserm, UMR1249, Parc Scientifique de Luminy, Aix-Marseille University, BP13, 13273, Marseille Cedex 09, France.
Background: Congenital cytomegalovirus (CMV) infections represent one leading cause of human neurodevelopmental disorders. Despite their high prevalence and severity, no satisfactory therapy is available and pathophysiology remains elusive. The pathogenic involvement of immune processes occurring in infected developing brains has been increasingly documented.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!