AI Article Synopsis
- The study aimed to assess how a static magnetic field from an intrauterine device (IUD) affects the tissue structure of the uterus in rats.
- The research included 20 female rats split into five groups, with variations in the type of IUD or magnet implanted, and their endometrial tissues were examined six days post-implantation.
- Results showed that both copper IUDs and intrauterine magnets led to immune cell infiltration in the uterus, with magnetic devices prompting more significant immune cell accumulation, suggesting they might improve contraceptive effectiveness and warrant further research.
Article Abstract
Objective: To evaluate the effects of an intrauterine device producing a static magnetic field on the endometrial histology of rats.
Methods: The experiments involved 20 adult female Wistar albino rats that were divided into five groups. Group 1 was sham-operated; Groups 2, 3 and 4 had a copper intrauterine device (IUD), an uncovered intrauterine magnet (IUM) or an intrauterine silicone-coated IUM, respectively, inserted into one of the uterine horns; in Group 5 an uncovered IUM was implanted subcutaneously. Six days later the rats were sacrificed; endometrial and subcutaneous tissues were harvested and examined microscopically.
Results: Copper IUDs caused classical cellular infiltration through the endometrium. IUMs, producing a static magnetic field, also caused leucocyte and monocyte infiltration of the endometrium and, in addition, a significant leucocyte accumulation over the endometrial surface.
Conclusion: This preliminary study reveals that an intrauterine magnet induces the accumulation of leucocytes in the uterine cavity in addition to the classic stromal infiltration caused by commercially available nonmagnetic IUDs. This activity could contribute to a greater efficacy of intrauterine contraception and should be investigated further.
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| http://dx.doi.org/10.3109/13625180903318259 | DOI Listing |
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