Objective: To investigate to what extent differences in diagnosed diabetes prevalence can be attributed to differences in the general practitioner's (GP) screening activity.
Design: An analysis of electronic patient files in combination with a survey among GPs. Setting. Ten primary healthcare centres with 44 GPs in the Netherlands.
Patients: General population (n = 58,919) and type 2 diabetic patients (n = 2582).
Main Outcome Measures: Each GP filled in a questionnaire with questions concerning screening methods for diabetes. The presence of diabetes and date of diagnosis were determined. The potential confounding variables age, sex, and postal code (which we used to determine socioeconomic status) were retrieved from patient records.
Results: The yearly point prevalence of diabetes increased significantly from 2.92% in 2000-2001 to 4.25% in 2005-2006 (p = 0.002). The incidence increased from 3.29/1000 person-years to 5.13/1000 person-years (p = 0.019). High screening activity of the general practitioner resulted in statistically significantly higher odds (1.35; p = 0.015) of being diagnosed as a patient with diabetes. The effect was independent of the influence of age, gender, and socioeconomic status.
Conclusion: Screening activity of the GP has a statistically significant and relevant influence on the prevalence of diagnosed diabetes. General practitioners should evaluate their screening activity to optimize the identification of diabetic patients.
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http://dx.doi.org/10.3109/02813430903226480 | DOI Listing |
Am J Surg Pathol
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Department of Pathology, Johns Hopkins University, Baltimore, MD.
Low-grade gliomas and reactive piloid gliosis can present with overlapping features on conventional histology. Given the large implications for patient treatment, there is a need for effective methods to discriminate these morphologically similar but clinically distinct entities. Using routinely available stains, we hypothesize that a limited panel including SOX10, p16, and cyclin D1 may be useful in differentiating mitogen-activated protein (MAP) kinase-activated low-grade gliomas from piloid gliosis.
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State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200030, P.R. China.
The rise of resistance to antiretroviral drugs due to mutations in human immunodeficiency virus-1 (HIV-1) protease is a major obstacle to effective treatment. These mutations alter the drug-binding pocket of the protease and reduce the drug efficacy by disrupting interactions with inhibitors. Traditional methods, such as biochemical assays and structural biology, are crucial for studying enzyme function but are time-consuming and labor-intensive.
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January 2025
State Key Laboratory of Integrated Optoelectronics, College of Electronics Science and Engineering, Jilin University, No. 2699 Qianjin Street, Changchun, Jilin 130012, P. R. China.
Hepatitis D virus (HDV) significantly influences the progression of liver diseases. Through clinical observations and database analyses, it has been established that patients coinfected with HDV and hepatitis B virus (HBV) experience accelerated progression toward cirrhosis, hepatocellular carcinoma (HCC), and liver failure compared to those infected solely with HBV. A higher viral load correlates with increased replicative activity, enhanced infectivity, and more severe disease manifestations.
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Department of Clinical Research, University of Southern Denmark, 5000 Odense, Denmark.
Background: Peyronie's disease (PD) is a fibrotic disorder affecting the penile tunica albugínea, with unclear pathophysiology despite centuries of recognition.
Aim: This scoping review maps the effects of interventions in basic PD research, synthesizing evidence from in vivo and in vitro studies to guide future investigation.
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Cureus
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Orthopaedics and Traumatology, Faculty of Medicine, Ondokuz Mayıs University, Samsun, TUR.
Aneurysmal bone cysts (ABCs) are aggressive, osteolytic lesions usually seen in childhood and young adulthood. The patient's age, location, and behavior of the lesion in the bone may cause patients to present with different clinical findings. Appropriate treatment of these rare, aggressive bone lesions is essential for recurrence.
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