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http://dx.doi.org/10.1176/ajp.148.3.395 | DOI Listing |
eNeuro
January 2025
Cognitive Psychology Unit, Faculty of Social Sciences, Leiden University, Wassenaarseweg 52 2333 AK, Leiden, Netherlands.
The brain attends to environmental rhythms by aligning the phase of internal oscillations. However, the factors underlying fluctuations in the strength of this phase entrainment remain largely unknown. In the present study we examined whether the strength of low-frequency EEG phase entrainment to rhythmic stimulus sequences varied with pupil size and posterior alpha-band power, thought to reflect arousal level and excitability of posterior cortical brain areas, respectively.
View Article and Find Full Text PDFNat Commun
January 2025
iHuman Institute, ShanghaiTech University, Shanghai, China.
The apelin receptor (APJR) emerges as a promising drug target for cardiovascular health and muscle regeneration. While prior research unveiled the structural versatility of APJR in coupling to Gi proteins as a monomer or dimer, the dynamic regulation within the APJR dimer during activation remains poorly understood. In this study, we present the structures of the APJR dimer and monomer complexed with its endogenous ligand apelin-13.
View Article and Find Full Text PDFCureus
November 2024
Department of Public Health and Environmental Medicine, The Jikei University School of Medicine, Tokyo, JPN.
Little is known about the effectiveness of pharmacotherapy in dissociative identity disorder (DID). Zinc is essential for proper brain function. Its deficiency can lead to mental health symptoms, possibly contributing to dissociation.
View Article and Find Full Text PDFACS Pharmacol Transl Sci
December 2024
Research and Development and Technology Transfer, Eurofins DiscoverX, LLC, 11180 Roselle Street Suite D, San Diego, California 92121, United States.
KRAS is an important oncogenic driver which is mutated in numerous cancers. Recent advances in the selective targeting of KRAS mutants via small molecule inhibitors and targeted protein degraders have generated an increase in research activity in this area in recent years. As such, there is a need for new assay platforms to profile next generation inhibitors which improve on the potency and selectivity of existing drug candidates, while evading the emergence of resistance.
View Article and Find Full Text PDFAnal Chem
December 2024
Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, P. R. China.
Deep and comprehensive understanding of the intricate biochemical processes mediated by HS ( ≥ 1), but not HS, is of paramount importance. A few fluorescent probes have been developed with the intention of addressing this issue. However, there is currently no evidence of any activatable NIR-II fluorescent probes for HS-specific imaging over HS.
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