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Conventional MRI-Based Structural Disconnection and Morphometric Similarity Networks and Their Clinical Correlates in Multiple Sclerosis.
Neurology
February 2025
Department of Advanced Biomedical Sciences, University "Federico II," Naples, Italy.
Background And Objectives: Although multiple sclerosis (MS) can be conceptualized as a network disorder, brain network analyses typically require advanced MRI sequences not commonly acquired in clinical practice. Using conventional MRI, we assessed cross-sectional and longitudinal structural disconnection and morphometric similarity networks in people with MS (pwMS), along with their relationship with clinical disability.
Methods: In this longitudinal monocentric study, 3T structural MRI of pwMS and healthy controls (HC) was retrospectively analyzed.
Effects of medications for opioid use disorder (MOUD) on fetal brain and cranial measurements.
Neurotoxicol Teratol
May 2023
College of Pharmacy Substance Use Research and Education Center, University of New Mexico Health Sciences Center, Albuquerque, NM, United States of America. Electronic address:
Background: The use and misuse of opioids, as well as opioid use disorder (OUD) have increased remarkably among reproductive-aged and pregnant women. As many as 25% of pregnant women who report non-medical opioid use in the past month also report concurrent alcohol use. While teratogenic effects of alcohol are well established, there are limited studies evaluating fetal intracranial effects associated with medications for OUD (MOUD) and concurrent use of MOUD and alcohol during pregnancy.
View Article and Find Full Text PDFThe Association Between Emotion Recognition, Affective Empathy, and Structural Connectivity in Schizophrenia Patients.
Front Psychiatry
June 2022
Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, Netherlands.
Introduction: Emotion processing deficits often occur in patients with schizophrenia. We investigate whether patients and controls differ in the association between facial emotion recognition and experience of affective empathy and whether performance on these emotion processing domains differently relates to white matter connectivity.
Materials And Methods: Forty-seven patients with schizophrenia and 47 controls performed an emotion recognition and affective empathy task.
Association of Maternal Prepregnancy Body Mass Index With Fetal Growth and Neonatal Thalamic Brain Connectivity Among Adolescent and Young Women.
JAMA Netw Open
November 2020
Children's Hospital Los Angeles, Los Angeles, California.
Importance: Higher maternal prepregnancy body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) is associated with adverse long-term outcomes for offspring, including obesity, poorer cognitive and social abilities, and increased risk of psychiatric disorders. Less clear is whether higher maternal BMI disrupts fetal growth and brain development.
Objective: To investigate the association of maternal prepregnancy BMI with fetal growth and neonatal functional connectivity.
Fronto-thalamic structural and effective connectivity and delusions in schizophrenia: a combined DTI/DCM study.
Psychol Med
September 2021
Translational Neuromodeling Unit (TNU), Institute for Biomedical Engineering, University of Zurich & ETH Zurich, Wilfriedstrasse 6, 8032, Zurich, Switzerland.
Background: Schizophrenia (SZ) is a complex disorder characterized by a range of behavioral and cognitive symptoms as well as structural and functional alterations in multiple cortical and subcortical structures. SZ is associated with reduced functional network connectivity involving core regions such as the anterior cingulate cortex (ACC) and the thalamus. However, little is known whether effective coupling, the directed influence of one structure over the other, is altered during rest in the ACC-thalamus network.
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