Introduction: Non-melanoma skin cancer (NMSC) increases the rate of morbidity and mortality in kidney transplant patients. Studies have shown that kidney transplanted patients have at least a 3-4-fold increased risk of cancers. Organ-transplanted (OT) patients therefore constitute a known and growing risk population. Careful information of the patient and prophylactic measures are thus strongly indicated.
Material And Methods: A questionnaire was sent to 110 kidney-transplanted patients in Region Sjaelland, Denmark. Patients were identified through Nephrology Departments. A total of 75 patients responded. The object of the questionnaire was to describe the level of information among the patients and the scope and frequency of any skin examination they underwent following transplantation.
Results: Responders did not differ from non-responders regarding gender and age. Among the responders, 22 (29%) had received oral information prior to transplantation and 38 (51%) after transplantation. A total of nine (12%) patients had received written information prior to transplantation and 18 (24%) after. In all, 39 (53%) were well-informed on their increased risk of NMSC. Only four patients (5%) had their skin and lymph nodes examined at follow-up visits by the physician responsible for the proper functioning of the transplant.
Conclusion: This study shows that kidney transplanted patients do not receive adequate information about increased risk of skin cancer and the necessity of photoprotection. Furthermore, the rate of examination by a dermatologist is very low. Both parameters could be improved by a structured plan for patient information and follow-up visits.
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Cancer Med
February 2025
Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
Introduction: Immune checkpoint inhibitors (ICI) have improved the therapeutic arsenal in outpatient oncology care; however, data on necessity of hospitalizations associated with immune-related adverse events (irAEs) are scarce. Here, we characterized hospitalizations of patients undergoing ICI, from the prospective cohort study of the immune cooperative oncology group (ICOG) Hannover.
Methods: Between 12/2019 and 06/2022, 237 patients were included.
BMC Rheumatol
January 2025
Department of Rheumatology, Overton Brooks VA Medical Center, Shreveport, LA, USA.
Background: Dermatomyositis is a chronic inflammatory condition affecting muscles and skin, often associated with an increased risk of cancer. Specific autoantibodies, including anti-TIF1 (Transcription Intermediary Factor 1), have been linked to this risk. We present a case of dermatomyositis in a male patient positive for anti-TIF1 antibodies, subsequently diagnosed with squamous cell carcinoma of the tonsil, a novel association not previously documented.
View Article and Find Full Text PDFNPJ Breast Cancer
January 2025
Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Endocrine therapy with CDK4/6 inhibitors is standard for estrogen receptor-positive, HER2-negative metastatic breast cancer (ER+/HER2- MBC), yet clinical resistance develops. Previously, we demonstrated that low doses of palbociclib activate autophagy, reversing initial G1 cell cycle arrest, while high concentrations induce off-target senescence. The autophagy inhibitor hydroxychloroquine (HCQ) induced on-target senescence at lower palbociclib doses.
View Article and Find Full Text PDFPhotodiagnosis Photodyn Ther
January 2025
Maebashi-Institute of Technology, Systems Life Engineering, Gunma, 371-0816 Japan. Electronic address:
Introduction: The successful diagnosis and treatment of early-stage breast cancer enhances the quality of life of patients. As a promising alternative to recently developed magnetic resonance imaging-guided radiotherapy, we proposed fluorescence molecular imaging-guided photodynamic therapy (FMI-guided PDT), which requires no expensive equipment. In the FMI simulations, ICG-C11 which has emission peaks at near-infrared wavelengths was used as the FMI agent.
View Article and Find Full Text PDFJ Invest Dermatol
January 2025
Department of Health Services Research University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
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