AI Article Synopsis
- The study investigates how the environment surrounding eggs, particularly the follicular fluid, influences fertilization and embryo development in couples undergoing Intracytoplasmic Sperm Injection (ICSI).
- It analyzes oxidative stress markers—specifically superoxide dismutase (SOD), catalase, and lipid peroxidation (LPO)—in the semen, blood serum, and follicular fluid of 208 infertile couples.
- Findings indicate high levels of follicular fluid SOD and catalase correlate with fertilization and cleavage rates, while increased LPO in follicular fluid is negatively linked to pregnancy rates, suggesting it could reflect metabolic activity necessary for pregnancy.
Article Abstract
The follicular fluid environment surrounding the oocytes may play a critical role in fertilization and subsequent embryo development. The goal of our study was to evaluate the oxidative stress markers in the semen, blood serum, and follicular fluid of couples undergoing Intracytoplasmic Sperm Injection (ICSI). Two hundred and eight infertile couples underwent ICSI and the levels of superoxide dismutase (SOD) and catalase and lipid peroxidation (LPO) were evaluated. Semen Catalase was highly correlated with fertilization and cleavage rates, but not with pregnancy rates. Fertilization and cleavage rates were correlated with the levels of SOD and Catalase in the follicular fluid. After adjusting for age, a negative correlation was detected between LPO levels in follicular fluid and pregnancy rates. Follicular fluid LPO levels may be a marker as a metabolic activity within the follicle need for establishing a pregnancy.
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| http://dx.doi.org/10.1080/14647270903207941 | DOI Listing |
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