Free radical scavenging abilities of flavonyl-thiazolidine-2,4-dione compounds.

Luminescence

Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Tandoğan, Ankara, Turkey.

Published: June 2011

Free radical scavenging activity of flavonyl-thiazolidine-2,4-dione compounds has been evaluated using chemiluminescence, electron spin resonance spectroscopy with 5,5-dimethyl-1-pyrroline-1-oxide as spin trap and DPPH (2,2'-diphenyl-1-picrylhydrazyl) method. The examined compounds exhibited 28-50% scavenging superoxide anion radical O₂⁻ⁱ16.7-76.7% hydroxyl radical (HO•) and 9-40% DPPH radical. Compounds containing carbonyl group in their structure can be considered as antioxidants with high relevance and great biological importance.

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http://dx.doi.org/10.1002/bio.1176DOI Listing

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