AI Article Synopsis
- Recent research suggests that GAB2 alleles affect the risk of late-onset Alzheimer's disease (LOAD), especially in individuals with the ApoEε4 allele, based on genome-wide studies.
- Some studies in Caucasian populations indicate a potential link between GAB2 polymorphisms and LOAD risk, although results are mixed.
- In this study involving Chinese Han participants, no significant association was found between the GAB2 SNPs rs2373115 and rs1385600, haplotypes, and LOAD, highlighting the need for further research with larger sample sizes to validate these findings.
Article Abstract
It has recently been shown that GAB2 alleles modify the risk for late-onset Alzheimer disease (LOAD) in apolipoprotein E (ApoE)epsilon4 allele carriers in a genome-wide association study. Some studies subsequently in Caucasians population, though not all, have demonstrated that GAB2 polymorphisms might be associated with LOAD susceptibility. The aim of this study is to evaluate the reported polymorphisms (rs2373115 and rs1385600) and GAB2 haplotypes (rs2373115-rs1385600) for an interaction with the ApoEepsilon4 allele in a cohort of Chinese LOAD. We conducted a case-control study in 292 LOAD and 227 non-demented controls from the Chinese Han population. Our study does not find any association between the two tested SNPs and GAB2 haplotypes and LOAD or any synergetic interaction between the SNPs and ApoE either. However, since the sample size required to show this point is large, our finding needs to be confirmed by a large independent sample of Chinese population.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10072-009-0178-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Translation and cultural adaption of MacLeod Clark professional identity scale among Chinese therapy students.
PLoS One
January 2025
Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom.
Background: Fostering a strong professional identity (PI) enhances career fulfillment. In China, therapy education is undergoing development, integrating both Western and traditional health concepts, causing inconsistent PI among therapy students. To date, no validated tools exist to measure and monitor PI of Chinese therapy students.
View Article and Find Full Text PDFFirst Report of Causing Black Leaf Spot on in China.
Plant Dis
January 2025
Zhejiang Academy of Agricultural Sciences, Institute of Agro-product Safety and Nutrition, Hangzhou, Zhejiang, China;
Chinese yam ( Turcz.), known for its nutrient-rich underground tubers, is both a food source and a traditional Chinese medicinal plant. It offers significant nutritional and medicinal benefits.
View Article and Find Full Text PDFAn InDel variant in the promoter of the NAC transcription factor MdNAC18.1 plays a major role in apple fruit ripening.
Plant Cell
December 2024
Shenzhen Research Institute, State Key Laboratory for Crop Stress Resistance and High-Efficiency Production/Shaanxi Key Laboratory of Apple, College of Horticulture, Northwest A&F University, Yangling 712100, China.
A complex regulatory network governs fruit ripening, but natural variations and functional differentiation of fruit ripening genes remain largely unknown. Utilizing a genome-wide association study (GWAS), we identified the NAC family transcription factor MdNAC18.1, whose expression is closely associated with fruit ripening in apple (Malus × domestica Borkh.
View Article and Find Full Text PDFReticular Synthesis of Covalent Organic Frameworks with kgd-v Topology and Trirhombic Pores.
J Am Chem Soc
January 2025
CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.
Two-dimensional (2D) covalent organic frameworks (COFs) with designable pore structures can be synthesized under the guidance of topology diagrams. Among the five existing edge-transitive topological nets, topology is considered a fine candidate for constructing COFs with ultramicropores. However, all of the reported COFs with topology need the use of -symmetric monomers, which are limited in compound type and difficult to synthesize.
View Article and Find Full Text PDFRelationship between the and the gene copy number variation and growth traits in different cattle breeds.
Anim Biotechnol
December 2025
Jilin Academy of Agricultural Sciences, Changchun, Jilin Province, China.
Copy number variations (CNV) are important genetic variations. The endogenous factors cobalamin receptor () and MIA SH3 domain ER-derived factor 3 () are associated with bone/muscle development and intramuscular fat deposition. There have been no reports on the effects of and CNVs on growth traits of Chinese cattle.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!