AI Article Synopsis
- The study investigates the relationship between elevated platelet serotonin (5-HT) levels in individuals with autism and its potential links to gut serotonin synthesis, metabolism, and melatonin production.
- Researchers compared urinary excretion of serotonin and its metabolite 5-HIAA between two groups of autistic individuals: those with normal serotonin levels and those with elevated levels (hyperserotonemic).
- Results suggest that while serotonin metabolism does not differ between the groups, there may be a need for further research to understand the connections between hyperserotonemia, gut serotonin, and melatonin levels.
Article Abstract
Objective: A substantial proportion of individuals with autism have elevated levels of platelet serotonin (5-HT). We examined whether platelet hyperserotonemia is associated with increased gut 5-HT synthesis, altered 5-HT catabolism or altered melatonin production.
Methods: Urinary excretion of 5-hydroxyindoleacetic acid (5-HIAA) and 5-HT was compared in 10 normoserotonemic and 10 hyperserotonemic age-matched autistic individuals. The relationship of urinary 6-sulfatoxymelatonin (6-SM) excretion to platelet 5-HT, and to urinary 5-HT and 5-HIAA excretion, was also examined.
Results: In the hyperserotonemic group, significant increases at trend level in urinary excretion of 5-HIAA (p = 0.061) and 5-HT (p = 0.071) and a significant decrease for 6-SM were found (p = 0.027). The urinary 5-HIAA:5-HT ratio was similar in the normo- versus the hyperserotonemic groups.
Conclusions: The catabolism of 5-HT does not differ in the groups, but greater exposure of the platelet to 5-HT cannot be ruled out as a cause of the platelet hyperserotonemia of autism. Although only trend level significant, the data point to a need for larger studies to examine more thoroughly the relationships between platelet hyperserotonemia, gut 5-HT synthesis and melatonin production.
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| http://dx.doi.org/10.1159/000258640 | DOI Listing |
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