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Alasmontamine A, A first tetrakis monoterpene indole alkaloid from Tabernaemontana elegans. | LitMetric
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Alasmontamine A, A first tetrakis monoterpene indole alkaloid from Tabernaemontana elegans.

Yusuke Hirasawa Saori Miyama Takahiro Hosoya Koichiro Koyama Abdul Rahman Idha Kusumawati Noor Cholies Zaini Hiroshi Morita

Org Lett

Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo 142-8501, Japan.

Published: December 2009

A novel tetrakis monoterpene indole alkaloid, alasmontamine A (1) consisting of bis-vobtusine-type skeletons, was isolated from the leaves of Tabernaemontana elegans. The structure including the relative stereochemistry was elucidated on the basis of spectroscopic data. Alasmontamine A (1) exhibited moderate cell growth inhibitory activity against HL-60 cells.

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http://dx.doi.org/10.1021/ol902420sDOI Listing

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