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Lack of progress in cancer related outcomes after Liver Transplantation: Mitigating risk & identifying future needs to move this needle.
Liver Transpl
October 2024
Department of Internal Medicine, Mayo Clinic, Rochester MN.
Malignancy has a crucial impact on long-term survival after liver transplantation. There has been enhanced early detection rates with refined cancer screening and improved prognosis for many cancer diagnoses in the general population with the advent of targetted anti-cancer therapies. Similar advancements have not occurred in the transplant population over this same timeframe.
View Article and Find Full Text PDFExploring the druggability of the UEV domain of human TSG101 in search for broad-spectrum antivirals.
Protein Sci
January 2025
Department of Physical Chemistry, Institute of Biotechnology, and Unit of Excellence in Chemistry Applied to Biomedicine and Environment, School of Sciences, University of Granada, Granada, Spain.
The ubiquitin E2 variant domain of TSG101 (TSG101-UEV) plays a pivotal role in protein sorting and virus budding by recognizing PTAP motifs within ubiquitinated proteins. Disruption of TSG101-UEV/PTAP interactions has emerged as a promising strategy for the development of host-oriented broad-spectrum antivirals with low susceptibility to resistance. TSG101 is a challenging target characterized by an extended and flat binding interface, low affinity for PTAP ligands, and complex binding energetics.
View Article and Find Full Text PDFOptogenetic Control of B. subtilis Gene Expression Using the CcaSR System.
Methods Mol Biol
December 2024
Systems, Synthetic, and Physical Biology Program, Rice University, Houston, TX, USA.
Optogenetics enables precise control of gene expression in a variety of organisms. We recently developed the first system for optogenetic control of transcription in Bacillus subtilis. This system is based on CcaSR, a light-responsive two-component regulatory system originally derived from Synechocystis PCC 6803.
View Article and Find Full Text PDFExosome-driven nano-immunotherapy: revolutionizing colorectal cancer treatment.
Mol Biol Rep
December 2024
Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Colorectal cancer (CRC) ranks as the third most common cancer worldwide and remains a major cause of cancer-related deaths, necessitating the development of innovative therapeutic approaches beyond conventional treatment modalities. Conventional therapies, such as radiation, chemotherapy, and surgery, are hindered by challenges like imprecise targeting, substantial toxicity, and the development of resistance. Exosome-driven nano-immunotherapy has emerged as a groundbreaking approach that leverages the natural properties of exosomes-cell-derived vesicles known for their role in intercellular communication-to deliver therapeutic agents with high precision and specificity.
View Article and Find Full Text PDFDeBo: Contrast enhancement for image registration using binary differential evolution and bat optimization.
PLoS One
December 2024
Shanghai Key Laboratory of Navigation and Location-based Services, School of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, P.R. China.
Image registration has demonstrated its significance as an essential tool for target recognition, classification, tracking, and damage assessment during natural catastrophes. The image registration process relies on the identification of numerous reliable features; thus, low resolutions, poor lighting conditions, and low image contrast substantially diminish the number of dependable features available for registration. Contrast stretching enhances image quality, facilitating the object detection process.
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