Objective: To investigate the level of awareness about tuberculosis (TB) in the public and associated factors in China.
Methods: Participants were recruited from 60 counties in 19 provinces and interviewed using a structured questionnaire. Questions asked covered the following areas: 1) overall TB awareness, 2) signs/symptoms of TB, 3) mode of TB transmission, 4) TB dispensaries, 5) free TB detection/treatment policy, 6) TB curability and 7) stigma attached to TB. Factors associated with TB awareness were examined using logistic regression.
Results: A total of 69 253 respondents aged 12-65 years were interviewed, revealing an overall TB awareness rate of 89.0% (95%CI 88.8-89.3). The awareness rates for TB symptoms, TB dispensaries and the free TB detection/treatment policy were respectively 15.1% (95%CI 14.8-15.4), 41.9% (95%CI 41.6-42.3) and 44.7% (95%CI 44.3-45.0). Approximately 71.9% (95%CI 71.6-72.3) had some extent of stigma towards patients with TB. People in the farming industry and those with low educational levels had poorer knowledge of all aspects of TB knowledge and were more likely to stigmatise TB.
Conclusions: Future TB control programmes in China should emphasise TB symptoms, TB dispensaries and its free TB detection/treatment policy to increase public TB awareness, and should target farm workers and people with low educational levels.
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Int J Mol Sci
December 2024
Laboratory of Epigenetics, Research Centre for Medical Genetics, Moskvorechie st., 1, 115522 Moscow, Russia.
Homologous recombination repair deficiency (HRD) is involved in the development of high-grade serous ovarian carcinoma (HGSOC) and its elevated sensitivity to platinum-based chemotherapy. To investigate the heterogeneity of the HRD-positive HGSOC we evaluated the HRD status, including BRCA mutations, genomic scar score, and methylation status of genes in 352 HGSOC specimens. We then divided the HRD-positive cohort into three molecular subgroups, the BRCA mutation cohort (BRCA+), BRCA1 methylation cohort (Meth+), and the rest of the HRD+ cohort (HRD+BRCA-Meth-), and evaluated their first-line chemotherapy response, benefit from olaparib, and progression-free survival (PFS).
View Article and Find Full Text PDFJ Pharmacopuncture
December 2024
Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Objectives: Among the various treatment methods involving the use of natural substances, pharmacopuncture using animal venom is a relatively new form of acupuncture that has been developed in South Korea and is gaining popularity worldwide. Pharmacopuncture with animal venom is widely used in clinical practice; therefore, ensuring its procedural safety is crucial. This study aimed to evaluate the safety and toxicity of pharmacopuncture using animal venom.
View Article and Find Full Text PDFEur Urol
December 2024
Department of Oncology, University of Debrecen, Debrecen, Hungary.
Objectives: Free clinics provide care to underserved populations nationwide. The Birmingham Free Clinic offers dermatology care and operates an onsite dispensary. Little is known about specialty care services and medication optimization in the free clinic setting.
View Article and Find Full Text PDFIntroduction: Recurrence of non-muscle-invasive bladder cancer (NMIBC) occurs in 70% of cases, and the risk of progression to muscle-invasive bladder cancer is 20%. Intravesical BCG therapy is indicated in order to increase relapse-free survival in patients with intermediate and high-risk NMIBC. We carried out a survey of Russian urologists on the use of intravesical BCG therapy in the treatment of NMIBC, and also presented the regulatory framework for the use of BCG for the treatment of bladder cancer.
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