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Cutaneous Mastocytosis with Persistent Blistering: Successful Treatment with Methylprednisolone and 3-Year Follow-Up Management.
Dermatol Ther (Heidelb)
June 2015
Department of Dermatology and Venereology, Medical University of Plovdiv, Plovdiv, Bulgaria,
Background: Mastocytosis is a rare disorder with diverse clinical manifestations. In cutaneous mastocytosis the mast cell infiltration is limited to the skin, but is often associated with systemic symptoms due to the release of mast cell mediators.
Case Report: We report a 6-month-old male infant who had skin lesions of various morphologies (macules, papules, plaques, and nodules) and sizes, persistent blistering and frequent flushing episodes for half a year.
Enterochromaffin cell hyperplasia and decreased serotonin transporter in a mouse model of postinfectious bowel dysfunction.
Neurogastroenterol Motil
December 2005
Wolfson Digestive Diseases Centre, University Hospital, Nottingham, UK.
Patients with postinfective irritable bowel syndrome and Trichinella spiralis-infected mice share many features including visceral hypersensitivity and disordered motility. We assessed enterochromaffin (EC) numbers and serotonin transporter (SERT) using National Institute of Health (NIH) female mice studied for up to 56 days post-T. spiralis infection.
View Article and Find Full Text PDFEffects of plain and controlled-ileal-release budesonide formulations in experimental ileitis.
Scand J Gastroenterol
October 1995
Aron M. Rappaport Microcirculation Laboratory, Sunnybrook Health Science Centre, Toronto, Ontario, Canada.
Background: Budesonide combines a topical anti-inflammatory activity with high first-pass hepatic extraction. This study compared the effects of plain and controlled-ileal-release (CIR) formulations of budesonide on intestinal inflammation.
Methods: Ileitis was induced in hamsters by an intraluminal injection of trinitrobenzene sulphonic acid.
Effects of tixocortol pivalate on gastrointestinal disease in systemic mastocytosis: a preliminary study.
Clin Exp Allergy
March 1991
Mast Cell Physiology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
Tixocortol pivalate is a steroid reportedly without significant adrenal-pituitary axis suppression when administered via the gastrointestinal tract. To determine whether this steroid would suppress the gastrointestinal manifestations of systemic mastocytosis, we performed an open clinical trial for safety and efficacy with tixocortal pivalate in four patients for periods of 8-15 weeks. All patients showed a decrease in the symptoms of abdominal pain and frequency of stools.
View Article and Find Full Text PDFInduction of granulopoiesis of mastocytoma cells: ultrastructural and cytochemical studies on production of serotonin in a cultured mouse mastocytoma cell line.
Virchows Arch B Cell Pathol Incl Mol Pathol
October 1987
Electron microscopic observations of an originally established mouse mastocytoma cell line (BSP-MST-2) revealed that the cytoplasm of many of the MST-2 cells contained small and low osmiophilic granules and a few mature electron-dense granules. Fluorescent- and immuno-histochemical examinations also suggested the immaturity of granules as the cytoplasmic reaction for serotonin (5-HT) was weak. Induction of further maturation of granules was investigated by administration of various chemical agents.
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