H(2)O(2) in combination with SOCl(2) proved to be a highly reactive reagent for the direct oxidative conversion of thiol derivatives to the corresponding sulfonyl chlorides with high purity through oxidative chlorination. Upon reaction with amines, the corresponding sulfonamides were obtained in excellent yields and in very short reaction times.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/jo901924m | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Determination of Amino Acids of Novel Food in Food by HPLC Coupled with Pre-Column Derivatization.
Foods
December 2024
Technical Center of Xiamen Customs, Xiamen 361013, China.
A method for simultaneous determination of Theanine and γ-aminobutyric acid (GABA), as the novel food of amino acids, which was established using pre-column derivatization and high-performance liquid chromatography (HPLC). 4-Dimethylaminoazobe nzene-4'-sulfonyl chloride (DABS-Cl) is employed as the derivatization reagent with chromophore linked to Theanine and GABA, which lacks chromophore for DAD analysis in its pristine structure. After the detection wavelength was confirmed, the chromatographic and derivatization conditions were also optimized, including the chromatographic column, mobile phases and their gradient, derivatization temperature and time, the additive amount of buffer solution and derivatization reagent.
View Article and Find Full Text PDFSulfoxidation of pyrimidine thioate derivatives and study their biological activities.
Sci Rep
January 2025
Chemistry Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt.
In a quest to innovate biologically active molecules, the benzoylation of 4,6-dimethylpyrimidine-2-thiol hydrochloride (1) with benzoyl chloride derivatives was employed to produce a series of pyrimidine benzothioate derivatives (2-5). Subsequent sulfoxidation of these derivatives (2-5) using hydrogen peroxide and glacial acetic acid yielded a diverse array of pyrimidine sulfonyl methanone derivatives (6-9). In parallel, the sulfoxidation of pyrimidine sulfonothioates (10-12) yielded sulfonyl sulfonyl pyrimidines (13-15), originating from the condensation of compound 1 with sulfonyl chloride derivatives.
View Article and Find Full Text PDFIntrinsically photosensitive polyimide photoresist and its double crosslinking mechanism.
Chem Commun (Camb)
December 2024
Shandong Provincial Key Laboratory of Photoresist, College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, P. R. China.
A new negative-working photoinitiator-free polyimide was developed for photolithographic processes. The polyimide introduced a photosensitive benzophenone unit into the backbone and a cross-linking group (methacrylate) into the side chains. A novel pre-functionalized diamine monomer was designed to avoid using corrosive sulfonyl chloride in the polyimide side-chain introduction step.
View Article and Find Full Text PDFAccess to 1-aryl-pyrazolin-5-ones photoinduced chemoselective cyclization of -methacrylo aldehyde hydrazones.
Chem Commun (Camb)
December 2024
School of Petrochemical Engineering, Changzhou University, Changzhou 213164, P. R. China.
A photocatalytic sulfamoylation/5- cyclization of ()-'-arylidene--phenylmethacrylohydrazides with sulfamoyl chlorides was developed. The chemoselective intramolecular addition of the carbon-centered radical intermediate to the CN bond in the hydrazone motif gave the sulfamoylated pyrazolin-5-one. Besides, sulfonyl chlorides are also suitable reaction partners to access sulfonylated pyrazolin-5-ones.
View Article and Find Full Text PDFPhotocatalytic Generation of β-Fluoroalkylated α-Carbonyl Carbocations.
Org Lett
December 2024
School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China.
Nucleophilic addition to α,β-unsaturated carbonyl compounds normally occurs at the carbonyl carbon or β-carbon. The direct α-nucleophilic addition at the α-carbon can hardly be achieved due to electronic mismatch. In this work, we report the nucleophilic addition of β-fluoroalkyl α-carbonyl carbocations that are prepared via -induced redox-neutral photocatalysis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!