Aim: To explore the role of Helicobacter pylori (H pylori) infection on the risk of digestive tract cancers.
Methods: In total, 199 oral squamous-cell carcinoma (SCC), 317 esophageal SCC, 196 gastric cardia and non-cardia adenocarcinoma and 240 colon adenocarcinoma patients were recruited for serum tests of H pylori infection. Two hospital- and one community-based control groups were used for the comparisons. H pylori seropositivity was determined by an enzyme linked immunosorbent assay method against H pylori IgG.
Results: Presence of H pylori infection was significantly inversely associated with esophageal SCC [adjusted odds ratio (AOR): 0.315-0.472, all P-value < 0.05] but positively associated with gastric adenocarcinoma (both cardia and non-cardia) (AOR: 1.636-3.060, all P-value < 0.05) in comparison to the three control groups. Similar results were not found in cancers of the oral cavity and colon.
Conclusion: Our findings support the finding that H pylori seropositivity is inversely associated with esophageal SCC risk, but increases the risk of gastric cardia adenocarcinoma.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778104 | PMC |
| http://dx.doi.org/10.3748/wjg.15.5465 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Seroprevalence of in a population of 15 to 35 years old in Mashhad.
Iran J Microbiol
December 2024
Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Background And Objectives: is a bacterium involved in gastrointestinal disorders with a high prevalence in Iran. We have determined the seroprevalence of in the young adult population of Mashhad city for the first time.
Materials And Methods: We carried out a cross-sectional study on 933 individuals between the ages of 15 and 35 in Mashhad.
Relationships among Helicobacter pylori seropositivity, the triglyceride-glucose index, and cardiovascular disease: a cohort study using the NHANES database.
Cardiovasc Diabetol
December 2024
Department of intensive care unit, China-Japan Union Hospital of Jilin University, No. 126 Xiantai Street, Changchun, 130033, China.
Background: Helicobacter pylori (H. pylori), a widely prevalent pathogen that can be cured through relatively simple medical methods, is thought to be potentially associated with the risk of cardiovascular diseases (CVD), although controversy remains. Currently, it is unclear whether the triglyceride-glucose index (TGI), a classic indicator of insulin resistance, influences the relationship between H.
View Article and Find Full Text PDFSeroprevalence of Helicobacter pylori and incident myocardial infarction - A population-based Swedish nested case-control study.
Int J Cardiol
February 2025
Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden; Department of Cardiology, Södersjukhuset, Stockholm, Sweden.
Aims: Helicobacter pylori (H. pylori) and its cytotoxin-associated gene A (CagA) have been associated with myocardial infarction (MI), but existing data are conflicting possibly due to limitations in study designs and lack of data on important confounders. The aim of this study was to determine whether H.
View Article and Find Full Text PDFThe association of Helicobacter pylori with adverse pregnancy outcomes in three European birth cohorts.
BMC Pregnancy Childbirth
November 2024
Barcelona Institute for Global Health (ISGlobal), Carrer Rosello 132, Barcelona, 08036, Spain.
Background: Helicobacter pylori is a prevalent infection that may complicate pregnancy, but evidence remains limited, controversial and may not apply to all pregnant women.
Objective: This study aims to evaluate whether Helicobacter pylori is a risk factor for adverse pregnancy outcomes and to identify vulnerable subpopulations.
Study Design: Multiplex serology was utilized to measure blood levels of immunoglobulin G against eight Helicobacter pylori antigens in 1372 pregnant women from three European birth cohorts: BiB (United Kingdom), Rhea (Greece) and INMA (Spain).
Decreased Serum Insulin Receptor Messenger RNA Level in IgG Seropositive Type 2 Diabetic Patients.
Biomark Insights
November 2024
Department of Biostatistics, School of Public Health, University of Ghana, Legon, Accra, Ghana.
Background: Helicobacter pylori (H. pylori) is a known gastro-intestinal pathogen but implicated in extra-gastric diseases. The relationship between H.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!