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Triple-drug antibiotic therapy for disseminated nocardial abscess in the mediastinum and brain of an immunocompetent patient: a case report.
BMC Infect Dis
January 2025
Department of Oncology, General Hospital of Western Theatre Command, No. 270, Tianhui Road, Rongdu Avenue, Jinniu District, Chengdu, Sichuan, 610000, People's Republic of China.
Background: Nocardia are widely present in nature and considered opportunistic pathogens. They can result in hematogenous spread infection through the ruptured skin or respiratory tract when the host's immune system is compromised. Currently, 119 species of Nocardia have been identified, with 54 capable of causing infections in humans.
View Article and Find Full Text PDFBrain abscesses in an immunocompromised patient with a soft tissue mass.
S Afr J Infect Dis
November 2024
Department of Infectious Diseases, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Unlabelled: Nocardiosis is a rare opportunistic infection and may be misdiagnosed as tuberculosis in the immunocompromised patient. This case report highlights the importance of doing tissue cultures in immunocompromised individuals to correctly identify spp. and initiate appropriate treatment timeously.
View Article and Find Full Text PDFA rare case of cerebellar abscess caused by .
Surg Neurol Int
November 2024
Faculty of Dental Medicine and Health Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.
Background: Gram-positive opportunistic bacteria of the species are responsible for a large spectrum of infections, such as pneumonia, skin infections, and more widespread conditions, including brain abscesses.
Case Description: A 67-year-old male patient suffered from headache, gait disorder, and vertigo for a week before admission to our department. An enhanced magnetic resonance imaging scan revealed a mediosagittal hyperintense infratentorial lesion with concomitant compression of the fourth ventricle.
Multicenter systematic review of clinical characteristics, diagnostic optimization, and personalized treatment for brain Nocardia infections.
Microb Pathog
January 2025
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China. Electronic address:
Article Synopsis
- - This systematic review analyzes 512 cases of Nocardia brain infections from 2000 to mid-2024, focusing on clinical symptoms, imaging results, and antibiotic resistance patterns in both immunocompromised and non-immunocompromised patients.
- - It highlights the shortcomings of traditional microbiological cultures in diagnosing these infections compared to advanced molecular methods, which improve detection speed and accuracy.
- - Key factors for better treatment outcomes include timely antibiotic administration (notably sulfonamides and β-lactams) and the potential need for surgical intervention, emphasizing the importance of improved diagnostic and treatment strategies.
Clinical profile of patients with surgical brain abscesses and etiology in a reference hospital.
J Infect Dev Ctries
September 2024
Neuropathology Department, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez, Ciudad de México, México.
Introduction: The annual incidence of brain abscesses is 1-2% in developed countries and up to 8% in developing countries. Our aim was to describe the profile and etiological agents of patients with surgical brain infections according to their nosological diagnosis on admission, and to analyze whether the initial diagnosis influenced the neurological deficit at discharge.
Methodology: This was an observational study with convenience sampling.
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