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The immunological perspective of major depressive disorder: unveiling the interactions between central and peripheral immune mechanisms.
J Neuroinflammation
January 2025
School of Nursing, Jinan University, No.601, West Huangpu Avenue, Guangzhou, 510632, Guangdong, China.
Major depressive disorder is a prevalent mental disorder, yet its pathogenesis remains poorly understood. Accumulating evidence implicates dysregulated immune mechanisms as key contributors to depressive disorders. This review elucidates the complex interplay between peripheral and central immune components underlying depressive disorder pathology.
View Article and Find Full Text PDFReactive Metabolites Cause Idiosyncratic Drug-Induced Liver Injury via Inflammasome Activation in Antigen-Presenting Cells.
J Appl Toxicol
January 2025
Department of Pharmacotherapeutics and Toxicology, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, Osaka, Japan.
Although the pathophysiology of idiosyncratic drug-induced liver injury (IDILI) is unclear, it is presumed to be immune-mediated, involving complex interactions between drug metabolism and activation of the immune system. The following four reactive metabolite production patterns are considered: (1) parent compounds into reactive metabolites within neutrophils or antigen-presenting cells (APCs), (2) reactive metabolites produced by cytochrome P450 (CYP), (3) nonreactive metabolites produced by CYP into reactive metabolites within APCs, and (4) reactive metabolites produced by non-CYPs. Reactive metabolites indirectly activate inflammasomes in APCs, leading to IDILIs.
View Article and Find Full Text PDFArtificial liver support systems bridge severe immune-mediated hepatotoxicity to clinical recovery.
Immunopharmacol Immunotoxicol
January 2025
Department of Medical Oncology, The First Affiliated Hospital of Zhejiang University School of Medicine, 310003 Hangzhou, China.
Background: The incidence of hepatic immune-related adverse events has increased with the wide use of immune checkpoint inhibitors, some immune-mediated hepatotoxicity cases are severe and lack of clinical recommendations.
Objective: This study aimed to evaluate the efficacy of artificial liver support systems (ALSS) in the treatment of immune-mediated hepatotoxicity.
Methods: This retrospective case series included six patients with grade 4 hepatotoxicity with high bilirubin induced by immune checkpoint inhibitors treated between January 1, 2019, to December 31, 2021.
High‑intensity focused ultrasound thermal ablation boosts the efficacy of immune checkpoint inhibitors in advanced cancers with liver metastases: A single‑center retrospective cohort study.
Oncol Lett
March 2025
State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, P.R. China.
High-intensity focused ultrasound thermal ablation (HIFU) is a novel non-invasive technique in the treatment of liver metastases (LIM) that allows focal destruction and is not affected by dose limits. This retrospective study aimed to explore the efficacy of HIFU in improving survival and the safety of the method in newly diagnosed patients with cancer with LIM who received first-line immune checkpoint inhibitor (ICI) therapy. Between January 2018 and December 2023, data from 438 newly diagnosed patients with cancer and LIM who were treated at Mianyang Central Hospital (Mianyang, China) were reviewed.
View Article and Find Full Text PDFSnow White's tale in nephrology: the emerging threat of skin-whitening creams on kidney health.
Clin Kidney J
January 2025
Department of Nephrology, Dialysis, Transplantation, Dr C. I. Parhon Hospital, Iasi, Romania.
The timeless tale of Snow White, with its emphasis on fair skin as a beauty ideal, mirrors a contemporary issue in nephrology: the harmful impact of skin-whitening creams on kidney health. Fairness creams have deeply embedded themselves in global society, driven by a pervasive obsession with lighter skin tones as a symbol of beauty. This widespread use reflects deeply rooted cultural beliefs and social norms, despite the significant health risks associated with these products.
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