Screening and testing of chemicals binding to estrogen receptors (ERs) emerge as an important issue in several regulatory programs or frameworks. Discrepancies exist, however, whether fish ERs should be included in the regulatory programs. In view of the differences in binding affinities to ERalpha and ERbeta and the significant contribution of ERbeta to biological effects of chemicals, it remains unknown whether both types of ERs are needed for the regulatory purposes. This study collected publications on binding affinities to both mammalian and fish ERs for 65 chemicals, covering a wide range of strong, moderate, weak and non-ER binders. Systematic evaluation of the data was performed in order to compare the difference in binding affinity of chemicals to fish and mammalian ERs and to subtypes of ERs. Except the reference estrogen 17beta-estradiol, all 64 chemicals have differential values of relative binding affinity (RBA), which result mostly from the inter-laboratory tests other than interspecies differences. It is concluded that ER binding in one vertebrate species or one subtype of ERs could be extrapolated to other species or subtypes of ERs for most of chemicals for the regulatory purpose. Fish ERs are likely more sensitive to some chemicals of weak binders than mammalian ERs, suggesting the importance of including fish ERs in the regulatory programs. Issues on data interpretation and testing strategy for the regulatory purpose have been discussed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.toxlet.2009.11.004 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Carbon dots induce endoplasmic reticulum stress-mediated lipid dysregulation and embryonic developmental toxicity in zebrafish.
Ecotoxicol Environ Saf
December 2024
Department of Toxicology, School of Public Health, Medical College of Soochow University, China. Electronic address:
Carbon dots (CDs) are widely utilized due to their exceptional physical and chemical properties. Nevertheless, there is a paucity of research examining the potential toxicity of carbon dots to human health, particularly with regard to developmental toxicity. The present study demonstrated that exposure to CDs resulted in increased mortality and malformations in zebrafish embryos.
View Article and Find Full Text PDFGrass Carp Reovirus (GCRV) infection activates the PERK-eIF2α pathway to promote the viral replication.
Fish Shellfish Immunol
December 2024
School of Biology & Basic Medical Science, Soochow University, Suzhou, 215123, China; Agricultural Biotechnology Research Institute, Agricultural Biotechnology, and Ecological Research Institute, Soochow University, Suzhou, 215123, China. Electronic address:
Grass carp reovirus (GCRV) belongs to the genus Aquareovirus and is responsible for causing serious hemorrhagic disease in grass carp (Ctenopharyngodon idella), characterized by high mortality rates. Numerous animal viruses have been shown to activate endoplasmic reticulum stress (ERS). However, the potential for GCRV infection to induce ERS and its implications for viral infection remain unclear.
View Article and Find Full Text PDFAntioxidant 1,2,3,4,6-Penta--galloyl-β-D-glucose Alleviating Apoptosis and Promoting Bone Formation Is Associated with Estrogen Receptors.
Molecules
October 2024
Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.
1,2,3,4,6-penta--galloyl-β-D-glucose (PGG) is the main phenolic active ingredient in , which is commonly used for the treatment of osteoporosis (OP). PGG is a potent natural antioxidant, and its effects on OP remain unknown. This study aimed to investigate the effects of PGG on promoting bone formation and explore its estrogen receptor (ER)-related mechanisms.
View Article and Find Full Text PDFTri-iso-butyl phosphate (TiBP) exposure induces neurotoxicity by triggering oxidative stress accompanied by neurotransmitter system disruptions and apoptosis in zebrafish larvae.
Environ Pollut
December 2024
Department of Preventive Medicine, Shantou University Medical College, Shantou, 515041, Guangdong, China. Electronic address:
Article Synopsis
- The research highlights the neurotoxic effects and potential molecular mechanisms of tris(1,3-dichloro-2-propyl) phosphate (TiBP), a key organophosphate flame retardant, using zebrafish larvae as a model.
- The study found that TiBP exposure resulted in significant developmental toxicity, indicated by increased heart rate, decreased body length, and impaired swimming, along with disrupted neurodevelopment and altered gene expression related to neurogenesis and neurotransmitter function.
- These neurotoxic effects were linked to oxidative stress, which led to increased levels of reactive oxygen species (ROS), apoptosis, and transcriptional dysregulation of neurotransmitter synthesis, indicating that oxidative stress is a critical molecular event in TiBP toxicity.
GCRV-encoded circRNA circ_20 forms a ternary complex with BIP and PERK to delay virus replication by inhibiting the PERK-eIF2α pathway.
Int J Biol Macromol
November 2024
School of Life Sciences, Soochow University, Suzhou 21523, China. Electronic address:
Article Synopsis
- Viral circRNAs, like circ_20 from the grass carp reovirus (GCRV), are shown to play crucial roles in regulating viral replication and host interactions.
- The study found that circ_20 negatively impacts processes like endoplasmic reticulum stress (ERS), the PERK pathway, and reactive oxygen species (ROS) production in GCRV-infected cells.
- circ_20 inhibits GCRV replication by forming a complex with BIP and PERK, and specific regions of circ_20 are critical for these interactions; disrupting them reduces the effectiveness of circ_20 in controlling GCRV proliferation.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!