AI Article Synopsis
- Magnetic nanoparticles (MNPs) are advanced imaging agents for magnetic resonance imaging, traditionally used for passive disease targeting but now being developed for specific cellular targeting and drug delivery.
- Recent advancements emphasize the importance of designing MNPs with optimal size, coating, and molecular functionalization to improve their effectiveness in biological systems.
- The review discusses the key design factors impacting MNP performance, including surface modifications and the chemistries used to enhance ligand activity while ensuring ideal physicochemical traits.
Article Abstract
Magnetic nanoparticles (MNPs) represent a class of non-invasive imaging agents that have been developed for magnetic resonance (MR) imaging. These MNPs have traditionally been used for disease imaging via passive targeting, but recent advances have opened the door to cellular-specific targeting, drug delivery, and multi-modal imaging by these nanoparticles. As more elaborate MNPs are envisioned, adherence to proper design criteria (e.g. size, coating, molecular functionalization) becomes even more essential. This review summarizes the design parameters that affect MNP performance in vivo, including the physicochemical properties and nanoparticle surface modifications, such as MNP coating and targeting ligand functionalizations that can enhance MNP management of biological barriers. A careful review of the chemistries used to modify the surfaces of MNPs is also given, with attention paid to optimizing the activity of bound ligands while maintaining favorable physicochemical properties.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827645 | PMC |
| http://dx.doi.org/10.1016/j.addr.2009.11.002 | DOI Listing |
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