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In Vitro Analysis of Tandem Peptides from Human CD5 and CD6 Scavenger Receptors as Potential Anti-Cryptococcal Agents.
J Fungi (Basel)
September 2024
Group of Immunoreceptors of the Innate and Adaptive System, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, Spain.
is included in the World Health Organization fungal priority pathogen list, complied to expedite improved research and public-health interventions. The limited number of available antifungal drugs, their associated toxicity, and the emergence of drug-resistant strains make the development of new therapeutic strategies mandatory. Pattern-recognition receptors (PRRs) from the host's innate immune system constitute a potential source of new antimicrobial agents.
View Article and Find Full Text PDFTIGIT expression on neoplastic cells is a poor prognostic factor for adult T-cell leukaemia/lymphoma.
Pathology
December 2024
Department of Pathology, Kurume University School of Medicine, Kurume, Japan.
Adult T-cell leukaemia/lymphoma (ATLL) is an aggressive peripheral T-cell neoplasm with a poor prognosis. T-cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domains (TIGIT) is an immune checkpoint receptor expressed on T and natural killer cells. Although increased TIGIT expression in the tumour microenvironment is associated with poor prognosis in various neoplasms, its relevance in ATLL remains unknown.
View Article and Find Full Text PDFEngineering Mesoscale T Cell Receptor Clustering by Plug-and-Play Nanotools.
Adv Mater
November 2024
Institute of Biochemistry, Biocenter, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438, Frankfurt am Main, Germany.
T cell receptor (TCR) clustering and formation of an immune synapse are crucial for TCR signaling. However, limited information is available about these dynamic assemblies and their connection to transmembrane signaling. In this work, TCR clustering is controlled via plug-and-play nanotools based on an engineered irreversible conjugation pair and a peptide-loaded major histocompatibility complex (pMHC) molecule to compare receptor assembly in a ligand (pMHC)-induced or ligand-independent manner.
View Article and Find Full Text PDFInvolvement of Siglec-15 in regulating RAP1/RAC signaling in cytoskeletal remodeling in osteoclasts mediated by macrophage colony-stimulating factor.
Bone Res
June 2024
Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, 060-8638, Japan.
DNAX-associated protein 12 kD size (DAP12) is a dominant immunoreceptor tyrosine-based activation motif (ITAM)-signaling adaptor that activates costimulatory signals essential for osteoclastogenesis. Although several DAP12-associated receptors (DARs) have been identified in osteoclasts, including triggering receptor expressed on myeloid cells 2 (TREM-2), C-type lectin member 5 A (CLEC5A), and sialic acid-binding Ig-like lectin (Siglec)-15, their precise role in the development of osteoclasts and bone remodeling remain poorly understood. In this study, mice deficient in Trem-2, Clec5a, Siglec-15 were generated.
View Article and Find Full Text PDFIdentification of the hybrid gene by long-read sequencing and implication of its novel signaling function.
Front Immunol
May 2024
Division of Biomedical Information Analysis, Medical Research Center for High Depth Omics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Article Synopsis
- Researchers studied leukocyte immunoglobulin-like receptors (LILRs) on chromosome 19, which show genetic variations across human populations and have complex genomic regions that are hard to characterize.
- They used a tool called JoGo-LILR CN Caller to analyze data from over 2,500 whole genome sequencing samples, discovering a novel large deletion in the Japanese population that affects three genes.
- This deletion creates a hybrid gene combining parts of two LILR genes, leading to potentially new signaling functions, with similar hybrid genes also identified in another population sample.
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