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A novel haplo-identical adoptive CTL therapy as a treatment for EBV-associated lymphoma after stem cell transplantation. | LitMetric

AI Article Synopsis

  • Epstein-Barr virus (EBV) can lead to serious conditions, like post-transplant lymphoproliferative disease (PTLD), especially in patients with weakened immune systems after organ transplants.
  • The traditional treatments for PTLD can be slow and costly, often arriving too late for the patient.
  • A new rapid method for isolating EBV-specific T cells was successfully used to treat and cure a PTLD patient using cells from her mother, showing promise for quicker treatments for similar conditions.

Article Abstract

Epstein-Barr virus (EBV)-related malignancies such as post-transplant lymphoproliferative disease (PTLD) are severe complications after allogeneic stem cell transplantation and solid-organ transplantation. In immunosuppressed transplant recipients, the activity of EBV-specific CTLs are often decreased or absent which leads to an increased risk of developing PTLD. If primary treatment modalities of PTLD fail, the most efficient way of treating the malignancy is adopting EBV-specific CTLs from the donor or, more recently, third-party donors. However, both are time consuming and expensive and often it is too late to administer cells to the patient. We have for the first time, using a rapid isolation protocol of EBV-specific T cells, treated and cured a patient suffering from PTLD with multiple-associated tissue lesions, using her haplo-identical mother as a donor. This treatment approach paves way for a new possibility to within-days treat patients with life-threatening EBV-associated malignancies.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11030917PMC
http://dx.doi.org/10.1007/s00262-009-0789-1DOI Listing

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