We propose a new mode adapter which allows more efficient launching of the optical power selectively in the fundamental mode of a multimode waveguide. Theoretical and experimental results confirm that such a mode adapter increases the performances in terms of coupling efficiency, coupling tolerances and transmitted power with respect to previously proposed solutions. Proof of principle of device operation is obtained with a simple Coupled Mode Theory model. Experimental results are obtained at a wavelength of 840 nm in Lithium Niobate Soft Proton Exchanged waveguides and agree very well with theoretical predictions.
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http://dx.doi.org/10.1364/OE.17.017868 | DOI Listing |
Protein Sci
January 2025
Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
This study focuses on spastic paraplegia type 50 (SPG50), an adapter protein complex 4 deficiency syndrome caused by mutations in the adapter protein complex 4 subunit mu-1 (AP4M1) gene, and on the downstream alterations of the AP4M1 protein. We applied a battery of heterogeneous computational resources, encompassing two in-house tools described here for the first time, to (a) assess the druggability potential of AP4M1, (b) characterize SPG50-associated mutations and their 3D scenario, (c) identify mutation-tailored drug candidates for SPG50, and (d) elucidate their mechanisms of action by means of structural considerations on homology models of the adapter protein complex 4 core. Altogether, the collected results indicate R367Q as the mutation with the most promising potential of being corrected by small-molecule drugs, and the flavonoid rutin as best candidate for this purpose.
View Article and Find Full Text PDFJ Sport Rehabil
November 2024
Department of Biomedical Engineering, Technion, Israel Institute of Technology, Haifa, Israel.
Context: The rate of force development (RFD), defined as the ability to rapidly generate muscle force, is commonly tested using an electromechanical dynamometer in isometric mode. However, these devices are expensive and not readily available. Therefore, this study aims to evaluate the interrater reliability of a fixed handheld dynamometer to measure the knee extensors' RFD and provide reference values using the proposed method.
View Article and Find Full Text PDFRespir Care
October 2024
Mss Fonzie and Willis are affiliated with Respiratory Care Services, Arkansas Children's Hospital, Little Rock, Arkansas.
Exp Lung Res
October 2024
Clinical Pharmacy Department, Faculty of Pharmacy, Beni-Suef University, Beni-suef, Egypt.
Several techniques had been developed to generate aerosolized medications during noninvasive ventilation (NIV) using variable inhalation methods. This study hypothesized that large spacers were more efficient significantly than small spacers and adapters during NIV. The main objective of this study was to compare the performance of newly developed spacers with standard T-piece in NIV chronic obstructive pulmonary disease (COPD) subjects.
View Article and Find Full Text PDFFarm Hosp
September 2024
Programa de Posgrado en Asistencia Farmacéutica, Universidad Federal de Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil.
Objective: To identify the administration characteristics and connection methods of bronchodilators by pressurized inhalers to the ventilatory circuit of patients under invasive mechanical ventilation.
Methods: A scope review was conducted following the PRISMA for Scoping Review, using the PubMed, Embase Elsevier, Cochrane Library, and Lilacs databases without language restrictions, up to July 2023. Eligible sources included reviews and consensuses (based on clinical studies), experimental and observational studies involving adult patients admitted to the Intensive Care Unit and undergoing invasive mechanical ventilation, regardless of the underlying condition, who used bronchodilator drugs contained in pressurized inhalers.
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