Purpose Of Review: To present recent experiences and studies on transcutaneous aortic valves implantation for severe aortic stenosis in elderly patients with high-risk profile.
Recent Findings: The surgical implantation of aortic valves is a highly efficient and safe procedure but some patients with a high-risk profile are denied surgery. Transcutaneous implantation of aortic valves has evolved as an alternative. Two major systems are available, the Edwards SAPIEN and the Medtronic CoreValve. Selection of patients is based on high age and elevated risk. The risk prediction of the scoring systems should be scrutinized. The anesthesiological approach has partly been determined by the procedural route. General anesthesia is used for transapical approach and transarterial procedures. Local anesthesia and awake or sedated patient can be used for transarterial approach. General anesthesia facilitates the use of perioperative transesophageal echocardiography.
Summary: Selection of patients is at present done by criteria such as age above 70-75 years and logistic European system for cardiac operative risk evaluation predicting a risk of death above 20%. The logistic European system for cardiac operative risk evaluation tends to overestimate risk, a fact that should be taken into consideration in patient selection. Trends indicate that the procedure may take a larger part of open surgery for aortic stenosis in the elderly. The consequences for the future of cardiac surgery remain to be seen.
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http://dx.doi.org/10.1097/ACO.0b013e3283346c07 | DOI Listing |
Am J Physiol Heart Circ Physiol
January 2025
Cardiovascular Translational Research. Navarrabiomed (Fundación Miguel Servet), Instituto de Investigación Sanitaria de Navarra (IdiSNA), Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), Pamplona, Spain.
Diabetes mellitus (DM) increases the risk of aortic stenosis (AS) and worsens its pathophysiology in a sex-specific manner. Aldosterone/mineralocorticoid receptor (Aldo/MR) pathway participates in early stages of AS and in other diabetic-related cardiovascular complications. We aim to identify new sex-specific Aldo/MR targets in AS complicated with DM.
View Article and Find Full Text PDFThe authors propose a modified transcatheter aortic valve replacement technique wherein the removal of the guidewire and delivery catheter immediately after the valve implantation helps to not only shorten the procedure but also decrease complications induced by the guidewire and delivery catheter.
View Article and Find Full Text PDFEur J Cardiothorac Surg
January 2025
Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA.
Objectives: The aim of this study was to determine the indication and optimal timing for performing a hemiarch procedure in patients undergoing valve-sparing root replacement (VSRR).
Methods: We conducted a retrospective study on 986 patients undergoing VSRR at three tertiary care centres. Inclusion criteria were all patients undergoing elective VSRR.
Echocardiography
January 2025
Cardiology Department, Soroka University Medical Center, Beer-Sheba, Israel.
Background: Timing of treatment of aortic stenosis (AS) is of key importance. AS severity is currently determined by transthoracic echocardiography (TTE) with a main focus on mean trans-aortic gradients. However, echocardiography has its limitations.
View Article and Find Full Text PDFCatheter Cardiovasc Interv
January 2025
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
Background: The long-term valve durability of supra-annular self-expanding valves (SEV) and intra-annular balloon-expandable valves (BEV) in patients with small aortic annuli remains unexplored.
Aims: This study aimed to determine the long-term bioprosthetic valve durability with SEV versus BEV in patients with small aortic annuli.
Methods: This retrospective study included patients with severe aortic stenosis (AS) and an aortic annulus area of 430 mm or less who underwent transcatheter aortic valve replacement using SEV and BEV between October 2009 and December 2022.
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