Enantioseparation in capillary electrophoresis using 6-oligo-(lactic acid)cyclomaltoheptaose as a chiral selector.

Anal Sci

School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P.R. China.

Published: November 2009

A novel beta-cyclodextrin (beta-CD) derivative modified with a degradable and biocompatible oligo(lactic acid) (OLA) group, 6-oligo(lactic acid)cyclomaltoheptaose (6-OLA-beta-CD), was successfully synthesized and used as a chiral selector for the capillary electrophoretic (CE) resolution (R(s)) of several basic analytes. The primary purpose of the research was to explore the capability of the 6-OLA-beta-CD as a chiral selector for comparisons with beta-CD and HP-beta-CD. Substitution with the oligo(lactic acid) group at the sixth hydroxyl sites of the CD is aimed at influencing the magnitude and selectivity of the analyte-CD interactions. The chiral resolution was strongly influenced by the concentration of the CDs and buffer pH. The effects of the substitution degree (DS) and the chain length (n) of the 6-oligo(lactic acid) groups of 6-OLA-beta-CD on separations were also investigated.

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http://dx.doi.org/10.2116/analsci.25.1315DOI Listing

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