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Platelet signaling in immune landscape: comprehensive mechanism and clinical therapy.
Biomark Res
December 2024
Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China.
Article Synopsis
- Platelets play a key role in blood clotting and are increasingly recognized for their involvement in immune-mediated inflammatory diseases.
- Resting platelets can be activated by immune complexes and other stimuli, leading to interactions with various immune cells and the release of immune activators.
- Targeting platelet activation and their interactions with immune and endothelial cells is a promising area for developing new therapeutic strategies.
Exploring the Effect of Resveratrol, Tyrosol, and Their Derivatives on Platelet-Activating Factor Biosynthesis in U937 Cells.
Molecules
November 2024
Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University, 70 Eleftheriou Venizelou Avenue Kallithea, 17676 Athens, Greece.
Platelet-activating factor (PAF) is a potent lipid mediator, involved in thrombosis, inflammation, and atherosclerosis. The protective effect of wine and olive oil against atherosclerotic diseases is largely attributed to their phenolic compounds and mostly to resveratrol and tyrosol. Both compounds have been reported to inhibit PAF biosynthesis in interleukin-1β (IL-1β)-stimulated monocytes and also to attenuate PAF biosynthesis in cell lysates.
View Article and Find Full Text PDFLysophosphatidylcholine Acyltransferase 2 Contributes to Increased Allergic and Irritant Inflammation in Mice.
Exp Dermatol
November 2024
Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Platelet-activating factor (PAF) is an important chemical mediator in the field of inflammation, but its function in the skin is unclear. To unravel the role of PAF, we focused on lysophosphatidylcholine acyltransferase 2 (LPCAT2 also called LPLAT9), a biosynthetic enzyme involved in PAF production, and investigated the role of PAF in allergic contact dermatitis (ACD) and irritant contact dermatitis (ICD). We measured the amount of PAF in the skin and investigated the ear swelling responses and leukocyte infiltration into the skin following the application of 2,4,6-trinitro-1-chlorobenzene (TNCB) or croton oil in wild-type (WT) and LPCAT2 knockout (LPCAT2-KO) mice.
View Article and Find Full Text PDFRe-Assessing the Role of Platelet Activating Factor and Its Inflammatory Signaling and Inhibitors in Cancer and Anti-Cancer Strategies.
Front Biosci (Landmark Ed)
September 2024
Laboratory of Biochemistry, Department of Chemistry, National and Kapodistrian University of Athens, 15771 Athens, Greece.
Since 2000s, we have outlined the multifaceted role of inflammation in several aspects of cancer, via specific inflammatory mediators, including the platelet activating factor (PAF) and PAF-receptor (PAFR) related signaling, which affect important inflammatory junctions and cellular interactions that are associated with tumor-related inflammatory manifestations. It is now well established that disease-related unresolved chronic inflammatory responses can promote carcinogenesis. At the same time, tumors themselves are able to promote their progression and metastasis, by triggering an inflammation-related vicious cycle, in which PAF and its signaling play crucial role(s), which usually conclude in tumor growth and angiogenesis.
View Article and Find Full Text PDFUnwinding the Threads of Mesoporous Silica Nanoparticles as Cutting-Edge for the Management of Inflammation: An Updated Review.
Curr Pharm Biotechnol
October 2024
Maharaja Agrasen School of Pharmacy, Maharaja Agrasen University, Baddi, Solan, Himachal Pradesh, 174103, India.
Article Synopsis
- Inflammation is a protective response to cellular damage, and while there are many therapies available, a new nanotechnology-based drug delivery system is needed to enhance treatment effectiveness.
- Mesoporous silica nanoparticles (MSNPs) are noted for their unique properties which can improve drug solubility, permeability, and bioavailability in treating various inflammatory conditions.
- The review discusses the role of specific inflammatory mediators and highlights the potential of MSNPs in treating neuroinflammation, inflammatory bowel disease, arthritic inflammation, lung inflammation, and enhancing herbal medicine delivery.
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